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Open AccessArticle

Controlled Release of Retinol in Cationic Co-Polymeric Nanoparticles for Topical Application

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Laboratoire LASEVE, Université du Québec à Chicoutimi, Département des Sciences Fondamentales, 555 Boulevard de l’Université, Saguenay, QC G7H 2B1, Canada
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Université de Lyon, Institut des Sciences Analytiques, UMR 5280 CNRS, Université Claude Bernard Lyon 1, 5 rue de la Doua, 69100 Villeurbanne, France
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Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 29; https://doi.org/10.3390/cosmetics7020029
Received: 18 March 2020 / Revised: 20 April 2020 / Accepted: 27 April 2020 / Published: 29 April 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Retinol is a compound used in many skin care formulations to act against skin conditions like acne, wrinkles, psoriasis, and ichthyosis. While retinol is used as an active ingredient, its efficacy is limited by an extreme sensitivity to light and temperature. Retinol can also generate toxicity at high concentrations. Microencapsulation is an alternative method to help overcome these issues. In this study, we develop a new encapsulation of retinol by solvent evaporation using a cationic polymer. We show that our particles have a narrow size distribution (350 nm), can encapsulate retinol with high efficiency, and protect it from oxidation for at least eight weeks. Finally, to demonstrate that the release of retinol from the particles can be controlled, we performed a kinetic study and showed that the particle releases the drug during 18 h. View Full-Text
Keywords: Encapsulation; solvent evaporation; drug release; retinol; drug delivery Encapsulation; solvent evaporation; drug release; retinol; drug delivery
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Goudon, F.; Clément, Y.; Ripoll, L. Controlled Release of Retinol in Cationic Co-Polymeric Nanoparticles for Topical Application. Cosmetics 2020, 7, 29.

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