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Open AccessArticle

Hemocompatible Chitin-Chitosan Composite Fibers

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Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya street. 29, 195251 Saint-Petersburg, Russia
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Almazov National Medical Research Centre, Akkuratova street 2, 194156 Saint-Petersburg, Russia
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Saint Petersburg State University of Industrial Technologies and Design, Bolshaya Morskaya street 18, 191186 Saint-Petersburg, Russia
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Institute of Macromolecular Compounds, Bolshoy pr. 31, 199004 Saint-Petersburg, Russia
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Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio 7, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 28; https://doi.org/10.3390/cosmetics7020028
Received: 11 March 2020 / Revised: 13 April 2020 / Accepted: 16 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Feature Papers in Cosmetics in 2020)
Composite chitosan fibers filled with chitin nanofibrils (CNF) were obtained by the wet spinning method. The paper discusses the mechanical properties of such type fibers and their hemocompatibility, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It was shown that low CNF concentration (about 0.5%) leads to an increase in fiber tensile strength due to the additional orientation of chitosan macromolecules. At the same time, with an increase in the content of CNF, the stability of the mechanical properties of composite fibers in a humid medium increases. All chitosan fibers, except 0.5% CNF, showed good hemocompatibility, even on prolonged contact with human blood. The addition of chitin nanofibers leads to decrease in hemoglobin molecules sorption due to the decline in optical density at wavelengths of 414 nm and 540 nm. Nevertheless, the hemolysis of fibers was comparable or even lesser that carbon hemosorbent, which is actively used in clinical practice. View Full-Text
Keywords: chitosan; chitin; hemocompatibility; mechanical characteristics chitosan; chitin; hemocompatibility; mechanical characteristics
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MDPI and ACS Style

Maevskaia, E.N.; Kirichuk, O.P.; Kuznetzov, S.I.; Dresvyanina, E.N.; Yudin, V.V.; Morganti, P. Hemocompatible Chitin-Chitosan Composite Fibers. Cosmetics 2020, 7, 28.

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