Next Article in Journal
The Potential Application of Spring Sargassum glaucescens Extracts in the Moisture-Retention of Keratinocytes and Dermal Fibroblast Regeneration after UVA-Irradiation
Next Article in Special Issue
Cosmetic Packaging to Save the Environment: Future Perspectives
Previous Article in Journal
Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study
Previous Article in Special Issue
A New Carrier for Advanced Cosmeceuticals
Article Menu

Export Article

Open AccessArticle

Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications

1
Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya ul. 29, 195251 Saint-Petersburg, Russia
2
Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bolshoy pr. VO, 199004 Saint-Petersburg, Russia
3
Saint-Petersburg State Pediatric Medical University, St. Petersburg, Litovskaya ul. 2y, 194100 Saint-Petersburg, Russia
4
Dermatol Unit, Campania University, L.Vanvitelli, 81100 Naples, Italy
*
Author to whom correspondence should be addressed.
Cosmetics 2019, 6(1), 16; https://doi.org/10.3390/cosmetics6010016
Received: 20 December 2018 / Revised: 20 February 2019 / Accepted: 26 February 2019 / Published: 1 March 2019
  |  
PDF [3633 KB, uploaded 1 March 2019]
  |  

Abstract

An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds. View Full-Text
Keywords: aliphatic copolyamide; chitosan; chitin nanofibrils; electrospinning; wound dressing; composite nanofibers; burns aliphatic copolyamide; chitosan; chitin nanofibrils; electrospinning; wound dressing; composite nanofibers; burns
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Shabunin, A.S.; Yudin, V.E.; Dobrovolskaya, I.P.; Zinovyev, E.V.; Zubov, V.; Ivan’kova, E.M.; Morganti, P. Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications. Cosmetics 2019, 6, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cosmetics EISSN 2079-9284 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top