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Open AccessArticle

ES2 as a Novel Verbascoside-Derived Compound in the Treatment of Cutaneous Wound Healing

1
Master Course in Cosmetic Science and Technology, Department Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy
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Deptartment of Food and Nutrition, Kyung Hee University, Seoul 130-701, Korea
3
Plants for Human Health Institute, Animal Sciences Department, NC Research Campus, NC State University, KannapolisRaleigh, NC 28081, USA
*
Author to whom correspondence should be addressed.
Cosmetics 2018, 5(4), 65; https://doi.org/10.3390/cosmetics5040065
Received: 29 September 2018 / Revised: 19 October 2018 / Accepted: 2 November 2018 / Published: 7 November 2018
Several pathologies are characterized by chronic wounds and often resistant to many of the common therapies, leading to chronic infections that can become even life-threatening for patients. For this reason, the identification of new products able to ameliorate the healing process is still an on-going research. Natural compounds have been used to improve skin conditions due to their dermo-cosmetic and therapeutic activities including anti-inflammatory, antioxidant and cell-migratory properties. Among these compounds, it has been recently demonstrated that Verbascoside, a phenyl propanoid glycoside widely used in the cosmetic field, can improve keratinocytes proliferation. Because of its high hydrophilic character, Verbascoside has a limited range of possible topical applications and the synthesis of ES2, a semi-synthetic derivative of Verbascoside was performed to bypass some of the drawback aspects of this molecule. In the present study, the wound healing properties of Verbascoside and ES2 were compared in both keratinocytes “in vitro” wound scratch and in wounded SKH1 mice. The results showed that both compounds were not cytotoxic and ES2 showed an efficient ability to promote the proliferation of human keratinocytes compared to Verbascoside. The findings were also confirmed in vivo but only at early time points (2/3 days). Taken together, these data suggest that the Verbascoside-derivative ES2 could be considered a novel and promising candidate for the topical treatment of wounds. View Full-Text
Keywords: dermo-cosmetic; Cutaneous tissue; keratinocytes; SKH1; natural derivative; biotechnology platform dermo-cosmetic; Cutaneous tissue; keratinocytes; SKH1; natural derivative; biotechnology platform
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Crivellari, I.; Vertuani, S.; Lim, Y.; Cervellati, F.; Baldisserotto, A.; Manfredini, S.; Valacchi, G. ES2 as a Novel Verbascoside-Derived Compound in the Treatment of Cutaneous Wound Healing. Cosmetics 2018, 5, 65.

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