Next Article in Journal
Headspace Solid-Phase Microextraction Gas Chromatography-Mass Spectrometry Analysis of Scent Profiles from Human Skin
Previous Article in Journal
Anti-Aging Efficacy of Melatonin-Based Cream: Clinical and Instrumental Skin Evaluation
Previous Article in Special Issue
Formulating O/W Emulsions with Plant-Based Actives: A Stability Challenge for an Effective Product
Article Menu

Export Article

Open AccessReview
Cosmetics 2018, 5(4), 61; https://doi.org/10.3390/cosmetics5040061

Endocrine Disruption by Mixtures in Topical Consumer Products

Abich Laboratories, 28924 Verbania, Italy
*
Author to whom correspondence should be addressed.
Received: 20 September 2018 / Revised: 11 October 2018 / Accepted: 12 October 2018 / Published: 16 October 2018
(This article belongs to the Special Issue Green Ingredients in Cosmetics and food)
Full-Text   |   PDF [279 KB, uploaded 16 October 2018]

Abstract

Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities. View Full-Text
Keywords: endocrine disrupting chemicals; cosmetics; consumer products; safety; phthalates; preservatives; parabens; benzoic acid; triclosan; formaldehyde; sunscreens; PBA endocrine disrupting chemicals; cosmetics; consumer products; safety; phthalates; preservatives; parabens; benzoic acid; triclosan; formaldehyde; sunscreens; PBA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ripamonti, E.; Allifranchini, E.; Todeschi, S.; Bocchietto, E. Endocrine Disruption by Mixtures in Topical Consumer Products. Cosmetics 2018, 5, 61.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cosmetics EISSN 2079-9284 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top