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Article

Whitening Agents from Reseda luteola L. and Their Chemical Characterization Using Combination of CPC, UPLC-HRMS and NMR

1
Université Côte d’Azur, CNRS, Institut de Chimie de Nice UMR7272, 06108 Nice, France
2
Université Européenne des Senteurs et des Saveurs, Pôle de Compétitivité Parfums, Arômes, Senteurs, Saveurs, Couvent des Cordeliers, 04300 Forcalquier, France
3
Parc naturel régional du Luberon, 60 place Jean Jaurès, 84400 Apt, France
*
Author to whom correspondence should be addressed.
Cosmetics 2017, 4(4), 51; https://doi.org/10.3390/cosmetics4040051
Received: 5 November 2017 / Revised: 22 November 2017 / Accepted: 23 November 2017 / Published: 25 November 2017
(This article belongs to the Special Issue Plants Used in Cosmetics)
Skin whitening agents occupy an important part of the dermo-cosmetic market nowadays. They are used to treat various skin pigmentation disorders, or simply to obtain a lighter skin tone. The use of traditional skin bleachers (e.g., hydroquinone, corticoids) is now strictly regulated due to their side effects. When considering this and the growing consumers’ interest for more natural ingredients, plant extracts can be seen as safe and natural alternatives. In this perspective, in vitro bioassays were undertaken to assess cosmetic potential of Reseda luteola, and particularly its promising whitening activities. A bioguided purification procedure employing centrifugal partition chromatography, Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-HRMS) and NMR was developed to isolate and identify the whitening agents (i.e., luteolin and apigenin) from aerial parts of R. luteola. UPLC-HRMS also enabled the characterization of acetylated luteolin- and apigenin-O-glycosides, which occurrence is reported for the first time in R. luteola. View Full-Text
Keywords: Reseda luteola; UPLC-HRMS; biological activity; centrifugal partition chromatography; luteolin; apigenin Reseda luteola; UPLC-HRMS; biological activity; centrifugal partition chromatography; luteolin; apigenin
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MDPI and ACS Style

Burger, P.; Monchot, A.; Bagarri, O.; Chiffolleau, P.; Azoulay, S.; Fernandez, X.; Michel, T. Whitening Agents from Reseda luteola L. and Their Chemical Characterization Using Combination of CPC, UPLC-HRMS and NMR. Cosmetics 2017, 4, 51. https://doi.org/10.3390/cosmetics4040051

AMA Style

Burger P, Monchot A, Bagarri O, Chiffolleau P, Azoulay S, Fernandez X, Michel T. Whitening Agents from Reseda luteola L. and Their Chemical Characterization Using Combination of CPC, UPLC-HRMS and NMR. Cosmetics. 2017; 4(4):51. https://doi.org/10.3390/cosmetics4040051

Chicago/Turabian Style

Burger, Pauline, André Monchot, Olivier Bagarri, Philippe Chiffolleau, Stéphane Azoulay, Xavier Fernandez, and Thomas Michel. 2017. "Whitening Agents from Reseda luteola L. and Their Chemical Characterization Using Combination of CPC, UPLC-HRMS and NMR" Cosmetics 4, no. 4: 51. https://doi.org/10.3390/cosmetics4040051

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