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Cosmetics 2017, 4(3), 21;

Ascorbyl Tetraisopalmitate Inclusion into Υ-Cyclodextrin and Mesoporous SBA-15: Preparation, Characterization and In Vitro Release Study

Prolabin & Tefarm S.r.l., R&D Department, Via dell’Acciaio 9, 06134 Perugia, Ponte Felcino, Italy
Author to whom correspondence should be addressed.
Received: 30 May 2017 / Revised: 20 June 2017 / Accepted: 29 June 2017 / Published: 1 July 2017
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Ascorbic acid or vitamin C is a strong antioxidant widely used in cosmetic and food fields. This vitamin is very unstable and rapidly undergoes degradation. In order to solve this problem and to obtain a stable ascorbic acid, Nikkol Group has developed ascorbyltetraisopalmitate (VC-IP). This raw material is an oil phase, already well-known and employed in the cosmetic market. The objective of this study is to obtain VC-IP in micro-powder form, in order to produce a new raw material that is easily dispersible in oil and water phases and useful for make-up and color cosmetic applications. Various types of drug carriers were studied and considered in order to support VC-IP and obtain the conversion in powder. Υ-cyclodextrin and mesoporous silica SBA-15 were chosen as the best candidates. A white powder of supported VC-IP was obtained with each carrier ([email protected], [email protected]). The systems underwent physicochemical characterization and in vitro release tests were carried out. Based on the conducted study, it can be concluded that by supporting VC-IP on Υ-cyclodextrin and SBA-15, it is feasible to obtain a new raw material in powder form. The two carriers possess different release profiles, adding the possibility to finely tune the release of the active component in smart formulations. View Full-Text
Keywords: ascorbic acid; hybrid materials; controlled release ascorbic acid; hybrid materials; controlled release

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Bastianini, M.; Sisani, M.; Petracci, A. Ascorbyl Tetraisopalmitate Inclusion into Υ-Cyclodextrin and Mesoporous SBA-15: Preparation, Characterization and In Vitro Release Study. Cosmetics 2017, 4, 21.

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