Evaluation of Sebum Control and Safety for Daily Use of a Cosmetic Elastomer Formulated with Vegetable Oils from Peruvian Biodiversity
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsThe manuscript provides an overview of a study aimed at evaluating a cosmetic elastomer formulated with vegetable oils for use in topical applications. The results of the study are promising. I have a few comments to improve the clarity and impact of the manuscript.
Table 1 - It would be useful to indicate the purity and origin of the individual raw materials
In Chapter 2.1 the homogenising equipment used and the rpm are missing.
Line 133 - indicates that the application rate was 0.5 g every 24 h, in line 212 states that the application rate was 0.2 g. Please consolidate your statements.
Line 139: give SD for the age of the volunteers. Add how many males and how many females participated in the study.
Combine sections 2.3.2 and 2.4.4 - repeating identical information
Chapter 2.3.3: What method was used to collect the Idil? Add to the Methodology.
Line 200: you state that the total number of participants in the study was 24, but in line 178 you state that 15 volunteers participated in the study.
Line 221: How could the measurements have been taken 2x side by side if the Semubeter SM 815 was used for the measurements?
Line 236: How were erythema, edema, papules or vesicles detected?
Figures 1-3: Units for sebum are not given and the legend is not in English. Unify figure captions.
Figure 4: Wrong figure caption.
Line 358: More appropriate to use units of µg/cm.
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsEvaluation of Sebum Control and Safety for Daily Use of a Cosmetic Elastomer Formulated with Vegetable Oils from Peruvian Biodiversity is good work, however, some concers are there--as
The correlation between sebum secretion and Acne vulgaris is to be mentioned in line between 50 to 54.
When natural sebum is deficient in ---------
It is advisable to mention the composition of natural sebum, then only write defiecent status of sebum.
The selection criterio of Plukenetia huayllabambana, Physalis peruviana, and Bertholletia excels must be mentioned that why researchers selected this for their study.
In table 01, what number indicates?
Vitamin E is not the trade name. Write the exact trade name in table 01.
Line 182-Inclusion Criterion-Phototype: I–VI, Fitzpatrick classification -----Line incomplete.
The forehead area was divided into two evaluation zones for evaluation. Some images of the same is to be added in suppl file.
In discussion section, numbering of references are not systematic. It should be arranged in sequential pattern.
Comments on the Quality of English LanguageThere is great scope to improve language and grammer
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Reviewer 3 Report
Comments and Suggestions for Authorslines 28-32: please rewrite this sentence, it gave the idea of that epidermis presents glands, but just presents the ducts.
lines 48-51: please include some statment that older people can also present oily skin.
De Melo, M. O., and Patrícia Maria Berardo G. Maia Campos. "Characterization of oily mature skin by biophysical and skin imaging techniques." Skin Research and Technology 24.3 (2018): 386-395.
line 57: P. acnes is not P. acnes anymore, but Cutibacterium acnes. Correct this during the whole paper.
Dréno, Brigitte, et al. "Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates." Journal of the European Academy of Dermatology and Venereology 32 (2018): 5-14.
rethink your figure 1 - it has spanish legend and please present in a different way, it is a little confuse. I could suggest two groups: with/without and the different time tables.
Why the authors divided in three groups? I see no point here. I strongly recommend that you should include all the participants in the same images, this division weakness your work and your statistics.
The authors should also present possible differences between male/female and with age.
lines 278-279: this is a little controversial. Actually the increase on temperature leads for a change in the sebum viscosity.
lines 307-309: do the authors think oils can penetrate in a significative amount and change skin physiology in this rate?
Choe, ChunSik, Jürgen Lademann, and Maxim E. Darvin. "Analysis of human and porcine skin in vivo/ex vivo for penetration of selected oils by confocal Raman microscopy." Skin pharmacology and physiology 28.6 (2015): 318-330.
Choe, ChunSik, et al. "In vivo confocal Raman microscopic determination of depth profiles of the stratum corneum lipid organization influenced by application of various oils." Journal of Dermatological Science 87.2 (2017): 183-191.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Comments and Suggestions for AuthorsI highly recommend that the article could be expanded in the Limitations chapter, the readers would appreciate a description of the limitations of the study which are obvious.
Reviewer 2 Report
Comments and Suggestions for AuthorsSignificant improvements done
