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Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study

1
Research Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, Russia
2
National Medical Research Center of Cardiology, 15A 3 Cherepkovskaya Str., 121552 Moscow, Russia
3
Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Str., 125315 Moscow, Russia
4
Centro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, Italy
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Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025 Moscow, Russia
6
Department of Molecular Basis of Ontogenesis, Belozersky Institute of Physical and Chemical Biology, Moscow State University, 119234 Moscow, Russia
7
Department of Internal Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei 108, Taiwan
*
Author to whom correspondence should be addressed.
Biology 2020, 9(3), 48; https://doi.org/10.3390/biology9030048
Received: 16 January 2020 / Revised: 29 February 2020 / Accepted: 3 March 2020 / Published: 6 March 2020
(This article belongs to the Section Medical Biology)
This randomized double-blinded, placebo-controlled clinical trial evaluated the progression of intima-media thickness of common carotid artery (cIMT) and the effect of phytoestrogen therapy on atherosclerosis development in early and late postmenopausal women. The 2-year cIMT progression was evaluated in 315 early postmenopausal women aged 40–55 years and in 231 late postmenopausal women aged 60–69 years free of cardiovascular disease. B-mode ultrasound was done at baseline and after 12 and 24 months of follow-up. The study revealed no significant changes in the rate of cIMT progression in 315 early postmenopausal women. By contrast, a statistically significant difference in the rate of atherosclerosis development was observed in late postmenopausal women treated with phytoestrogens compared to placebo (p = 0.008). The rate of cIMT progression in the placebo group was 0.019 mm/year led to a significant increase of cIMT during the observation period (p = 0.012), while the rate of cIMT progression in phytoestrogen late postmenopausal recipients was 0.011 mm/year, and total change did not reach statistical significance during the follow-up period (p = 0.101). These results suggest that late postmenopausal women can be a suitable cohort for trials assessing the anti-atherosclerosis effects of phytoestrogen preparations. In particular, the beneficial effect of phytoestrogens on cIMT progression was demonstrated in late postmenopausal women. View Full-Text
Keywords: women; postmenopause; cIMT progression; atherosclerosis; phytoestrogens women; postmenopause; cIMT progression; atherosclerosis; phytoestrogens
MDPI and ACS Style

Kirichenko, T.V.; Myasoedova, V.A.; Ravani, A.L.; Sobenin, I.A.; Orekhova, V.A.; Romanenko, E.B.; Poggio, P.; Wu, W.-K.; Orekhov, A.N. Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study. Biology 2020, 9, 48. https://doi.org/10.3390/biology9030048

AMA Style

Kirichenko TV, Myasoedova VA, Ravani AL, Sobenin IA, Orekhova VA, Romanenko EB, Poggio P, Wu W-K, Orekhov AN. Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study. Biology. 2020; 9(3):48. https://doi.org/10.3390/biology9030048

Chicago/Turabian Style

Kirichenko, Tatiana V., Veronika A. Myasoedova, Alessio L. Ravani, Igor A. Sobenin, Varvara A. Orekhova, Elena B. Romanenko, Paolo Poggio, Wei-Kai Wu, and Alexander N. Orekhov 2020. "Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study" Biology 9, no. 3: 48. https://doi.org/10.3390/biology9030048

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