Next Article in Journal
Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility
Previous Article in Journal
A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs
Open AccessCase Report

Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study

1
Research Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, Russia
2
National Medical Research Center of Cardiology, 15A 3 Cherepkovskaya Str., 121552 Moscow, Russia
3
Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Str., 125315 Moscow, Russia
4
Centro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, Italy
5
Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025 Moscow, Russia
6
Department of Molecular Basis of Ontogenesis, Belozersky Institute of Physical and Chemical Biology, Moscow State University, 119234 Moscow, Russia
7
Department of Internal Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei 108, Taiwan
*
Author to whom correspondence should be addressed.
Biology 2020, 9(3), 48; https://doi.org/10.3390/biology9030048
Received: 16 January 2020 / Revised: 29 February 2020 / Accepted: 3 March 2020 / Published: 6 March 2020
(This article belongs to the Section Medical Biology)
This randomized double-blinded, placebo-controlled clinical trial evaluated the progression of intima-media thickness of common carotid artery (cIMT) and the effect of phytoestrogen therapy on atherosclerosis development in early and late postmenopausal women. The 2-year cIMT progression was evaluated in 315 early postmenopausal women aged 40–55 years and in 231 late postmenopausal women aged 60–69 years free of cardiovascular disease. B-mode ultrasound was done at baseline and after 12 and 24 months of follow-up. The study revealed no significant changes in the rate of cIMT progression in 315 early postmenopausal women. By contrast, a statistically significant difference in the rate of atherosclerosis development was observed in late postmenopausal women treated with phytoestrogens compared to placebo (p = 0.008). The rate of cIMT progression in the placebo group was 0.019 mm/year led to a significant increase of cIMT during the observation period (p = 0.012), while the rate of cIMT progression in phytoestrogen late postmenopausal recipients was 0.011 mm/year, and total change did not reach statistical significance during the follow-up period (p = 0.101). These results suggest that late postmenopausal women can be a suitable cohort for trials assessing the anti-atherosclerosis effects of phytoestrogen preparations. In particular, the beneficial effect of phytoestrogens on cIMT progression was demonstrated in late postmenopausal women. View Full-Text
Keywords: women; postmenopause; cIMT progression; atherosclerosis; phytoestrogens women; postmenopause; cIMT progression; atherosclerosis; phytoestrogens
MDPI and ACS Style

Kirichenko, T.V.; Myasoedova, V.A.; Ravani, A.L.; Sobenin, I.A.; Orekhova, V.A.; Romanenko, E.B.; Poggio, P.; Wu, W.-K.; Orekhov, A.N. Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study. Biology 2020, 9, 48.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop