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Open AccessArticle

Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility

1
Department of Natural Sciences, Sabaragamuwa University, Belhiloya 70140, Sri Lanka
2
Department of Zoology, Faculty of Applied Sciences (Center for Biotechnology), University of Sri Jayewardenepura, Nugegoda 10250, Sri Lanka
*
Author to whom correspondence should be addressed.
Biology 2020, 9(3), 49; https://doi.org/10.3390/biology9030049
Received: 24 December 2019 / Revised: 28 February 2020 / Accepted: 2 March 2020 / Published: 7 March 2020
(This article belongs to the Section Behavior Biology)
Pesticides are known to result in toxic insult. We aimed to evaluate Judo 40, the commercial formulation of chlorpyrifos on the neurological activities, fertility, and hormone levels of male rats. Male Wistar rats were treated orally with 1 mL of 20 or 50 mg/kg Judo 40. The doses were administered four times, twice a day. Sexual and exploratory behavior indices, fertility indices, serum androgen levels, blood acetylcholinesterase (BChE) levels, and neurological and muscular effects were evaluated. Serum testosterone and luteinizing hormone were significantly reduced in the rats receiving 50 mg/kg Judo 40. A reduction in viable implantation sites and live pups born were evident in the female rats mated with the male rats treated with the highest dose. Similarly, in the rats treated with the highest dose of Judo 40, a significant reduction in plasma BChE enzyme was observed. According to the results, prolonged Judo 40 exposure can cause impairment of the neurological alterations and sex hormones leading to impaired fertility. Therefore, chemical handlers should be educated on protection and risk minimization. View Full-Text
Keywords: Judo 40; chemical formulation; chlorpyrifos; organophosphate; sexual behavior; pain perception; fertility index Judo 40; chemical formulation; chlorpyrifos; organophosphate; sexual behavior; pain perception; fertility index
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MDPI and ACS Style

Kudavidanage, E.P.; Dissanayake, D.M.I.; Keerthirathna, W.L.R.; Nishshanke, N.L.W.; Peiris, L.D.C. Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility. Biology 2020, 9, 49.

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