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The Emergence of Physiology and Form: Natural Selection Revisited
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Open AccessConcept Paper
Biology 2016, 5(2), 17;

Life Is Simple—Biologic Complexity Is an Epiphenomenon

Evolutionary Medicine Program, University of California, Los Angeles, CA 90095, USA
Academic Editor: Jukka Finne
Received: 17 February 2016 / Revised: 29 March 2016 / Accepted: 20 April 2016 / Published: 27 April 2016
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Life originated from unicellular organisms by circumventing the Second Law of Thermodynamics using the First Principles of Physiology, namely negentropy, chemiosmosis and homeostatic regulation of calcium and lipids. It is hypothesized that multicellular organisms are merely contrivances or tools, used by unicellular organisms as agents for the acquisition of epigenetic inheritance. The First Principles of Physiology, which initially evolved in unicellular organisms are the exapted constraints that maintain, sustain and perpetuate that process. To ensure fidelity to this mechanism, we must return to the first principles of the unicellular state as the determinants of the primary level of selection pressure during the life cycle. The power of this approach is reflected by examples of its predictive value. This perspective on life is a “game changer”, mechanistically rendering transparent many dogmas, teleologies and tautologies that constrain the current descriptive view of Biology. View Full-Text
Keywords: evolution; life cycle; First Principles of Physiology; unicell; negentropy; chemiosmosis; homeostasis; exaptation evolution; life cycle; First Principles of Physiology; unicell; negentropy; chemiosmosis; homeostasis; exaptation

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Torday, J.S. Life Is Simple—Biologic Complexity Is an Epiphenomenon. Biology 2016, 5, 17.

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