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T Cells in Fish

Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa 252-0880, Japan
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Academic Editor: Brian Dixon
Biology 2015, 4(4), 640-663; https://doi.org/10.3390/biology4040640
Received: 2 August 2015 / Revised: 11 September 2015 / Accepted: 14 September 2015 / Published: 25 September 2015
(This article belongs to the Special Issue Current Understanding of Fish Immune Systems)
Cartilaginous and bony fish are the most primitive vertebrates with a thymus, and possess T cells equivalent to those in mammals. There are a number of studies in fish demonstrating that the thymus is the essential organ for development of T lymphocytes from early thymocyte progenitors to functionally competent T cells. A high number of T cells in the intestine and gills has been reported in several fish species. Involvement of CD4+ and CD8α+ T cells in allograft rejection and graft-versus-host reaction (GVHR) has been demonstrated using monoclonal antibodies. Conservation of CD4+ helper T cell functions among teleost fishes has been suggested in a number studies employing mixed leukocyte culture (MLC) and hapten/carrier effect. Alloantigen- and virus-specific cytotoxicity has also been demonstrated in ginbuna and rainbow trout. Furthermore, the important role of cell-mediated immunity rather than humoral immunity has been reported in the protection against intracellular bacterial infection. Recently, the direct antibacterial activity of CD8α+, CD4+ T-cells and sIgM+ cells in fish has been reported. In this review, we summarize the recent progress in T cell research focusing on the tissue distribution and function of fish T cells. View Full-Text
Keywords: T cells; CD4; CD8; Thymus; Cytotoxicity T cells; CD4; CD8; Thymus; Cytotoxicity
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Nakanishi, T.; Shibasaki, Y.; Matsuura, Y. T Cells in Fish. Biology 2015, 4, 640-663.

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