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Review

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

1
Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia
2
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
3
Division of Genetics and Molecular Biology, Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur 50603, Malaysia
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Institute of Marine Sciences, Shantou University, Shantou 515063, China
5
Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia
*
Authors to whom correspondence should be addressed.
Equal contribution.
Academic Editor: Francisco Les
Biology 2021, 10(4), 287; https://doi.org/10.3390/biology10040287
Received: 8 March 2021 / Revised: 23 March 2021 / Accepted: 30 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Bioactivity of Medicinal Plants and Extracts)
This review highlights the medicinal benefits of a natural remedy, the Carica papaya extracts and its phytochemicals. In this review, the potential of Carica papaya against various conditions, including cancer, inflammation, aging, healing of the skin, and lifelong diseases has been summarized and discussed. In short, more research and development should focus on this natural remedy that can potentially act as a prophylaxis against chronic diseases.
Oxidative stress is a result of disruption in the balance between antioxidants and pro-oxidants in which subsequently impacting on redox signaling, causing cell and tissue damages. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases and cancers but these conditions can be managed properly with the aid of antioxidants. This review features various studies to provide an overview on how Carica papaya help counteract oxidative stress via various mechanisms of action closely related to its antioxidant properties and eventually improving the management of various oxidative stress-related health conditions. Carica papaya is a topical plant species discovered to contain high amounts of natural antioxidants that can usually be found in their leaves, fruits and seeds. It contains various chemical compounds demonstrate significant antioxidant properties including caffeic acid, myricetin, rutin, quercetin, α-tocopherol, papain, benzyl isothiocyanate (BiTC), and kaempferol. Therefore, it can counteract pro-oxidants via a number of signaling pathways that either promote the expression of antioxidant enzymes or reduce ROS production. These signaling pathways activate the antioxidant defense mechanisms that protect the body against both intrinsic and extrinsic oxidative stress. To conclude, Carica papaya can be incorporated into medications or supplements to help manage the health conditions driven by oxidative stress and further studies are needed to investigate the potential of its chemical components to manage various chronic diseases. View Full-Text
Keywords: oxidative stress; antioxidant; Carica papaya; inflammation; diabetes; cancer; aging; wound healing; periodontal disease; Alzheimer’s disease oxidative stress; antioxidant; Carica papaya; inflammation; diabetes; cancer; aging; wound healing; periodontal disease; Alzheimer’s disease
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MDPI and ACS Style

Kong, Y.R.; Jong, Y.X.; Balakrishnan, M.; Bok, Z.K.; Weng, J.K.K.; Tay, K.C.; Goh, B.H.; Ong, Y.S.; Chan, K.G.; Lee, L.H.; Khaw, K.Y. Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review. Biology 2021, 10, 287. https://doi.org/10.3390/biology10040287

AMA Style

Kong YR, Jong YX, Balakrishnan M, Bok ZK, Weng JKK, Tay KC, Goh BH, Ong YS, Chan KG, Lee LH, Khaw KY. Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review. Biology. 2021; 10(4):287. https://doi.org/10.3390/biology10040287

Chicago/Turabian Style

Kong, Yew R., Yong X. Jong, Manisha Balakrishnan, Zhui K. Bok, Janice K.K. Weng, Kai C. Tay, Bey H. Goh, Yong S. Ong, Kok G. Chan, Learn H. Lee, and Kooi Y. Khaw. 2021. "Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review" Biology 10, no. 4: 287. https://doi.org/10.3390/biology10040287

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