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Article

Shape-Memory Nanofiber Meshes with Programmable Cell Orientation

1
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan
2
Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan
3
Graduate School of Industrial Science and Technology, Tokyo University of Science, Katsushika, Tokyo 125-8585, Japan
4
International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan
5
Department of Materials Science and Technology, Tokyo University of Science, Katsushika, Tokyo 125-8585, Japan
*
Author to whom correspondence should be addressed.
Fibers 2019, 7(3), 20; https://doi.org/10.3390/fib7030020
Received: 14 February 2019 / Revised: 25 February 2019 / Accepted: 25 February 2019 / Published: 1 March 2019
(This article belongs to the Special Issue Electrospun Polymer Nanofibers for Food and Health Applications)
In this work we report the rational design of temperature-responsive nanofiber meshes with shape-memory properties. Meshes were fabricated by electrospinning poly(ε-caprolactone) (PCL)-based polyurethane with varying ratios of soft (PCL diol) and hard [hexamethylene diisocyanate (HDI)/1,4-butanediol (BD)] segments. By altering the PCL diol:HDI:BD molar ratio both shape-memory properties and mechanical properties could be readily turned and modulated. Though mechanical properties improved by increasing the hard to soft segment ratio, optimal shape-memory properties were obtained using a PCL/HDI/BD molar ratio of 1:4:3. Microscopically, the original nanofibrous structure could be deformed into and maintained in a temporary shape and later recover its original structure upon reheating. Even when deformed by 400%, a recovery rate of >89% was observed. Implementation of these shape memory nanofiber meshes as cell culture platforms revealed the unique ability to alter human mesenchymal stem cell alignment and orientation. Due to their biocompatible nature, temperature-responsivity, and ability to control cell alignment, we believe that these meshes may demonstrate great promise as biomedical applications. View Full-Text
Keywords: shape memory nanofiber; shape memory polymer; poly(ε-caprolactone); melting temperature; cell orientation; polyurethane shape memory nanofiber; shape memory polymer; poly(ε-caprolactone); melting temperature; cell orientation; polyurethane
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MDPI and ACS Style

Niiyama, E.; Tanabe, K.; Uto, K.; Kikuchi, A.; Ebara, M. Shape-Memory Nanofiber Meshes with Programmable Cell Orientation. Fibers 2019, 7, 20. https://doi.org/10.3390/fib7030020

AMA Style

Niiyama E, Tanabe K, Uto K, Kikuchi A, Ebara M. Shape-Memory Nanofiber Meshes with Programmable Cell Orientation. Fibers. 2019; 7(3):20. https://doi.org/10.3390/fib7030020

Chicago/Turabian Style

Niiyama, Eri, Kanta Tanabe, Koichiro Uto, Akihiko Kikuchi, and Mitsuhiro Ebara. 2019. "Shape-Memory Nanofiber Meshes with Programmable Cell Orientation" Fibers 7, no. 3: 20. https://doi.org/10.3390/fib7030020

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