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Article

Traditional Herbal Remedies with a Multifunctional Therapeutic Approach as an Implication in COVID-19 Associated Co-Infections

1
Centre of Biotechnology, Nehru Science Complex, University of Allahabad, Prayagraj 211002, Uttar Pradesh, India
2
Department of Pathology, Motilal Nehru Medical College, Prayagraj 211001, Uttar Pradesh, India
3
Unit of Translational Surgery and Vascular Diseases Center, Ferrara University Hospital, 44124 Ferrara, Italy
4
Department of Morphology, Surgery & Experimental Medicine and Centre of Hemostasis & Thrombosis University of Ferrara, 44124 Ferrara, Italy
5
Department of Bioengineering, Northeastern University, Boston, MA 02115, USA
6
Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8–10, 10589 Berlin, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Coatings 2020, 10(8), 761; https://doi.org/10.3390/coatings10080761
Received: 9 July 2020 / Revised: 29 July 2020 / Accepted: 3 August 2020 / Published: 5 August 2020
(This article belongs to the Special Issue Antiviral Coating as Sustainable Measure to Fight Viral Pandemic)
Co-infection in patients with viral infection as a predisposing factor is less focused on during epidemic outbreaks, resulting in increased morbidity and mortality. Recent studies showed that patients with coronavirus disease 2019 (COVID-19) often have both bacterial and fungal co-infections. In this study, sputum samples of 120 OPD (outdoor patients) suffering from respiratory tract infection (RTI) but negative for tuberculosis infection were collected with informed consent. Morphological, biochemical, and resistance criteria were used to classify isolates and to distinguish multidrug resistant (MDR) isolates, which were further classified on a molecular basis. We found that the isolates, including MDR strains, showed remarkable sensitivity against acetone and methanol extracts of Moringa oleifera, Adhatoda vasica, and Cassia fistula. The results strongly confirmed that multifactorial infections can produce MDR characteristics against antimicrobial drugs, which gave insight into the use of herbal drugs with their age-old traditional importance as having antiviral, antibacterial, antifungal, anti-inflammatory, and immunomodulatory effects. We conclude that apart from this, the anti-infective potential of these plants can be used in the future in the form of products such as cosmetics, pharmaceutical coatings, surface coatings, drug delivery vehicle coatings, and other bioengineered coatings for public use. Future studies are required to assess therapeutics for co-infective resistant strains and nosocomial infections with immune-enhancing effects, thereby promoting their function in holistic treatment and therapy of COVID-19 patients. View Full-Text
Keywords: viral infection; antifungal; antibiotics; multidrug resistant; plant extracts; immunomodulators; surface coatings viral infection; antifungal; antibiotics; multidrug resistant; plant extracts; immunomodulators; surface coatings
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MDPI and ACS Style

Tiwari Pandey, A.; Pandey, I.; Zamboni, P.; Gemmati, D.; Kanase, A.; Singh, A.V.; Singh, M.P. Traditional Herbal Remedies with a Multifunctional Therapeutic Approach as an Implication in COVID-19 Associated Co-Infections. Coatings 2020, 10, 761. https://doi.org/10.3390/coatings10080761

AMA Style

Tiwari Pandey A, Pandey I, Zamboni P, Gemmati D, Kanase A, Singh AV, Singh MP. Traditional Herbal Remedies with a Multifunctional Therapeutic Approach as an Implication in COVID-19 Associated Co-Infections. Coatings. 2020; 10(8):761. https://doi.org/10.3390/coatings10080761

Chicago/Turabian Style

Tiwari Pandey, Aprajita, Ishan Pandey, Paolo Zamboni, Donato Gemmati, Anurag Kanase, Ajay V. Singh, and Mohan P. Singh 2020. "Traditional Herbal Remedies with a Multifunctional Therapeutic Approach as an Implication in COVID-19 Associated Co-Infections" Coatings 10, no. 8: 761. https://doi.org/10.3390/coatings10080761

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