Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections
Abstract
:1. Introduction
2. Ibrexafungerp
2.1. Mechanism of Action
2.2. In Vitro and In Vivo Activity
2.3. Pharmacokinetics
2.4. Clinical Development
3. Ibrexafungerp for Candida auris
3.1. In Vitro Activity
3.2. In Vivo Activity
3.3. Clinical Experience
3.4. Echinocandin Resistance and C. auris
4. Summary and Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Disclaimer
References
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Drug (No. of Isolates) | MIC50 a | Modal MIC | MIC Range |
---|---|---|---|
Ibrexafungerp (n = 122) | 0.5 | 0.5 | 0.06–2 |
Anidulafungin | 0.125 | 0.06 | 0.016–>32 |
Micafungin | 0.125 | 0.125 | 0.03–>32 |
Amphotericin B | 1 | 1 | 0.5–1 |
Fluconazole | ≥64 | ≥64 | 0.5–≥64 |
Voriconazole | 0.5 | Bimodal | ≤0.004–4 |
Isavuconazole | 0.125 | Trimodal | ≤0.004–2 |
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Ghannoum, M.; Arendrup, M.C.; Chaturvedi, V.P.; Lockhart, S.R.; McCormick, T.S.; Chaturvedi, S.; Berkow, E.L.; Juneja, D.; Tarai, B.; Azie, N.; et al. Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections. Antibiotics 2020, 9, 539. https://doi.org/10.3390/antibiotics9090539
Ghannoum M, Arendrup MC, Chaturvedi VP, Lockhart SR, McCormick TS, Chaturvedi S, Berkow EL, Juneja D, Tarai B, Azie N, et al. Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections. Antibiotics. 2020; 9(9):539. https://doi.org/10.3390/antibiotics9090539
Chicago/Turabian StyleGhannoum, Mahmoud, Maiken Cavling Arendrup, Vishnu P. Chaturvedi, Shawn R. Lockhart, Thomas S. McCormick, Sudha Chaturvedi, Elizabeth L. Berkow, Deven Juneja, Bansidhar Tarai, Nkechi Azie, and et al. 2020. "Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections" Antibiotics 9, no. 9: 539. https://doi.org/10.3390/antibiotics9090539