Candida auris Bloodstream Infections in Russia
Almazov National Medical Research Centre, 2 Akkuratova str., 197341 St. Petersburg, Russia
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Antibiotics 2020, 9(9), 557; https://doi.org/10.3390/antibiotics9090557
Received: 31 July 2020
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Revised: 22 August 2020
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Accepted: 28 August 2020
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Published: 30 August 2020
(This article belongs to the Special Issue Diagnosis,Resistance and Treatment of Infections by Candida auris)
Candida auris—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of C. auris bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread of C. auris. The South Asian lineage of the studied strains was indicated by K143R substitution in ERG11 gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates from C. auris candidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate in C. auris bloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication of C. auris from blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management of C. auris infections are needed.
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Keywords:
treatment; echinocandins; azoles; susceptibility; amphotericin B; mortality; attributable mortality; risk factors; K143R substitution; EGR11 gene; phylogenetic analysis
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MDPI and ACS Style
Barantsevich, N.E.; Vetokhina, A.V.; Ayushinova, N.I.; Orlova, O.E.; Barantsevich, E.P. Candida auris Bloodstream Infections in Russia. Antibiotics 2020, 9, 557. https://doi.org/10.3390/antibiotics9090557
AMA Style
Barantsevich NE, Vetokhina AV, Ayushinova NI, Orlova OE, Barantsevich EP. Candida auris Bloodstream Infections in Russia. Antibiotics. 2020; 9(9):557. https://doi.org/10.3390/antibiotics9090557
Chicago/Turabian StyleBarantsevich, Natalia E., Antonina V. Vetokhina, Natalia I. Ayushinova, Olga E. Orlova, and Elena P. Barantsevich. 2020. "Candida auris Bloodstream Infections in Russia" Antibiotics 9, no. 9: 557. https://doi.org/10.3390/antibiotics9090557
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