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Antibiotics
Volume 9
Issue 8
10.3390/antibiotics9080496
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Article

Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains

by
María-José Valderrama
1,*,
María Alfaro
2,
Icíar Rodríguez-Avial
2,
Elvira Baos
2,
Carmen Rodríguez-Avial
3 and
Esther Culebras
2,3
1
Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, 28040 Madrid, Spain
2
Hospital Clínico San Carlos, 28040 Madrid, Spain
3
Departamento de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(8), 496; https://doi.org/10.3390/antibiotics9080496
Submission received: 6 July 2020 / Revised: 31 July 2020 / Accepted: 6 August 2020 / Published: 9 August 2020
(This article belongs to the Special Issue Methicillin-Resistant Staphylococci)
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Abstract

Linezolid is a synthetic oxazolydinone active against multi-resistant Gram-positive cocci that inhibits proteins synthesis by interacting with the 50S ribosomal subunit. Although linezolid-resistant strains are infrequent, several outbreaks have been recently described, associated with prolonged treatment with the antibiotic. As an alternative to monotherapy, the combination of different antibiotics is a commonly used option to prevent the selection of resistant strains. In this work, we evaluated combinations of linezolid with classic and new aminoglycosides (amikacin, gentamicin and plazomicin), carbapenems (doripenem, imipenem and meropenem) and fosfomycin on several linezolid- and methicillin-resistant strains of Staphylococcus aureus and S. epidermidis, isolated in a hospital intensive care unit in Madrid, Spain. Using checkerboard and time-kill assays, interesting synergistic effects were encountered for the combination of linezolid with imipenem in all the staphylococcal strains, and for linezolid–doripenem in S.epidermidis isolates. The combination of plazomicin seemed to also have a good synergistic or partially synergistic activity against most of the isolates. None of the combinations assayed showed an antagonistic effect.
Keywords: Staphylococcus spp.; linezolid resistance; plazomicin; synergy Staphylococcus spp.; linezolid resistance; plazomicin; synergy

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MDPI and ACS Style

Valderrama, M.-J.; Alfaro, M.; Rodríguez-Avial, I.; Baos, E.; Rodríguez-Avial, C.; Culebras, E. Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains. Antibiotics 2020, 9, 496. https://doi.org/10.3390/antibiotics9080496

AMA Style

Valderrama M-J, Alfaro M, Rodríguez-Avial I, Baos E, Rodríguez-Avial C, Culebras E. Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains. Antibiotics. 2020; 9(8):496. https://doi.org/10.3390/antibiotics9080496

Chicago/Turabian Style

Valderrama, María-José, María Alfaro, Icíar Rodríguez-Avial, Elvira Baos, Carmen Rodríguez-Avial, and Esther Culebras. 2020. "Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains" Antibiotics 9, no. 8: 496. https://doi.org/10.3390/antibiotics9080496

APA Style

Valderrama, M.-J., Alfaro, M., Rodríguez-Avial, I., Baos, E., Rodríguez-Avial, C., & Culebras, E. (2020). Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains. Antibiotics, 9(8), 496. https://doi.org/10.3390/antibiotics9080496

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