Next Article in Journal
Knowledge, Attitudes and Practices of Veterinarians Towards Antimicrobial Resistance and Stewardship in Nigeria
Next Article in Special Issue
From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria
Previous Article in Journal
Clinical Experience with High-Dose Polymyxin B against Carbapenem-Resistant Gram-Negative Bacterial Infections—A Cohort Study
Previous Article in Special Issue
Isolation and Biological Properties of the Natural Flavonoids Pectolinarin and Pectolinarigenin—A Review
Open AccessReview

The Desotamide Family of Antibiotics

1
Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
2
Astbury Centre for Structural Molecular Biology, School of Chemistry, University of Leeds, Leeds LS2 9JT, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Thu V. Vuong
Antibiotics 2020, 9(8), 452; https://doi.org/10.3390/antibiotics9080452
Received: 19 June 2020 / Revised: 14 July 2020 / Accepted: 25 July 2020 / Published: 27 July 2020
Microbial natural products underpin the majority of antimicrobial compounds in clinical use and the discovery of new effective antibacterial treatments is urgently required to combat growing antimicrobial resistance. Non-ribosomal peptides are a major class of natural products to which many notable antibiotics belong. Recently, a new family of non-ribosomal peptide antibiotics were discovered—the desotamide family. The desotamide family consists of desotamide, wollamide, surugamide, ulleungmycin and noursamycin/curacomycin, which are cyclic peptides ranging in size between six and ten amino acids in length. Their biosynthesis has attracted significant attention because their highly functionalised scaffolds are cyclised by a recently identified standalone cyclase. Here, we provide a concise review of the desotamide family of antibiotics with an emphasis on their biosynthesis. View Full-Text
Keywords: natural products; non-ribosomal peptides; NRPS; standalone enzymes; cyclases natural products; non-ribosomal peptides; NRPS; standalone enzymes; cyclases
Show Figures

Figure 1

MDPI and ACS Style

Fazal, A.; Webb, M.E.; Seipke, R.F. The Desotamide Family of Antibiotics. Antibiotics 2020, 9, 452. https://doi.org/10.3390/antibiotics9080452

AMA Style

Fazal A, Webb ME, Seipke RF. The Desotamide Family of Antibiotics. Antibiotics. 2020; 9(8):452. https://doi.org/10.3390/antibiotics9080452

Chicago/Turabian Style

Fazal, Asif; Webb, Michael E.; Seipke, Ryan F. 2020. "The Desotamide Family of Antibiotics" Antibiotics 9, no. 8: 452. https://doi.org/10.3390/antibiotics9080452

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop