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The Antimicrobial Activity of Cannabinoids

Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne 3010, VIC, Australia
Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne 3800, VIC, Australia
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(7), 406;
Received: 5 June 2020 / Revised: 8 July 2020 / Accepted: 10 July 2020 / Published: 13 July 2020
A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens that are resistant to current drugs. Therefore, there is an urgent need to discover new classes of potent antimicrobial agents with novel modes of action. Cannabis sativa is an herbaceous plant that has been used for millennia for medicinal and recreational purposes. Its bioactivity is largely due to a class of compounds known as cannabinoids. Recently, these natural products and their analogs have been screened for their antimicrobial properties, in the quest to discover new anti-infective agents. This paper seeks to review the research to date on cannabinoids in this context, including an analysis of structure–activity relationships. It is hoped that it will stimulate further interest in this important issue. View Full-Text
Keywords: antibiotics; antimicrobial resistance; MRSA; Cannabis sativa; cannabinoids; structure–activity relationships antibiotics; antimicrobial resistance; MRSA; Cannabis sativa; cannabinoids; structure–activity relationships
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Figure 1

MDPI and ACS Style

Karas, J.A.; Wong, L.J.M.; Paulin, O.K.A.; Mazeh, A.C.; Hussein, M.H.; Li, J.; Velkov, T. The Antimicrobial Activity of Cannabinoids. Antibiotics 2020, 9, 406.

AMA Style

Karas JA, Wong LJM, Paulin OKA, Mazeh AC, Hussein MH, Li J, Velkov T. The Antimicrobial Activity of Cannabinoids. Antibiotics. 2020; 9(7):406.

Chicago/Turabian Style

Karas, John A., Labell J.M. Wong, Olivia K.A. Paulin, Amna C. Mazeh, Maytham H. Hussein, Jian Li, and Tony Velkov. 2020. "The Antimicrobial Activity of Cannabinoids" Antibiotics 9, no. 7: 406.

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