Search Results (8,484)

The concept of virtual water is currently one of the most important issues in water resource management, especially in a context marked by structural water scarcity. Beyond the analysis of virtual water flows, which has been widely studied in the literature, this study aims to better understand the relationship between virtual water exports and economic growth. This paper analyzes the dynamic relationship between Morocco’s economic growth and agricultural virtual water exports to the European Union over the period of 1986–2023. An ARDL model was used based on annual data to test cointegration and estimate short- and long-term effects, controlling for gross fixed capital formation and agricultural value added. The bounds test confirms the existence of a stable long-term relationship between the variables. The results suggest that export specialization may be associated with foreign earnings and agricultural activity while also coinciding with greater pressure on resources and potential adaptation costs, especially for blue water resources. However, estimates indicate that in the long term, investment is positively and significantly associated with growth, while virtual water exports are associated with a negative effect on GDP, suggesting that export gains may be offset by increasing water constraints and sectoral trade-offs, and that agricultural value added mainly influences short-term dynamics. The results highlight the importance of integrating water footprint and virtual water trade concepts, as well as climate constraints, into agricultural and trade strategy planning while strengthening policies on water efficiency, innovation, and governance. Full article

This study examines the determinants of carbon dioxide (CO₂) emissions across 25 European Union countries over the period 2000–2021, with particular emphasis on the roles of environmental taxation and green innovation in shaping environmental sustainability. The analysis is grounded in ecological modernization theory, endogenous growth theory, and the Environmental Kuznets Curve hypothesis, which collectively explain the long-run and dynamic interactions between environmental policy, economic activity, structural transformation, and environmental outcomes. To ensure robust empirical inference, this study applies a comprehensive econometric framework that accounts for cross-sectional dependence, heterogeneity, non-stationarity, cointegration, and endogeneity. The empirical strategy begins with Pesaran cross-sectional dependence tests and slope heterogeneity diagnostics, followed by second-generation panel unit root tests (Pesaran CADF/CIPS) and Westerlund cointegration tests to establish the existence of long-run equilibrium relationships among the variables. Long-run coefficients are estimated using Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS), Canonical Cointegrating Regression (CCR), and Common Correlated Effects Mean Group (CCEMG) estimators. In addition, the Panel Autoregressive Distributed Lag (ARDL) model is employed to capture both short-run dynamics and long-run adjustment processes, while the System Generalized Method of Moments (System GMM) estimator addresses potential endogeneity, reverse causality, omitted variable bias, and dynamic persistence in CO₂ emissions. The empirical results indicate that environmental taxation has a positive and statistically significant association with CO₂ emissions, suggesting that current fiscal environmental policies in EU-25 countries may not yet be sufficiently effective in discouraging pollution-intensive activities. In contrast, green innovation is found to significantly reduce CO₂ emissions, underscoring the critical role of innovation-driven environmental investment and technological progress in improving environmental quality. Economic growth, exports, and urbanization are associated with higher emissions, while imports contribute to emission reductions, reflecting differences between domestic production-based effects and trade-related structural adjustments. The System GMM results further confirm the persistence of CO₂ emissions over time and validate the robustness of the long-run relationships identified by alternative estimators. Likewise, the CCEMG and Panel ARDL results support the stability and consistency of the findings under conditions of cross-sectional dependence and heterogeneous country dynamics. Taken together, the results highlight the importance of integrating environmental taxation with green innovation policies, innovation-driven investment, and sustainable trade policies to achieve long-term emission reductions in the European Union. This study contributes to the environmental economics literature by providing robust empirical evidence using second-generation panel econometric techniques that explicitly address cross-sectional dependence, heterogeneity, and endogeneity in the analysis of environmental sustainability. Full article

Using data from the 41 companies listed on the Borsa Istanbul Sustainability Index between 2020 and 2024, this study examines the relationship between board characteristics, concentrated ownership structure, shareholder activism and sustainability transparency. Reports published on a voluntary basis were subjected to content analysis based on criteria selected from the Global Reporting Initiative (GRI) standards, and a sustainability disclosure score was calculated. The relationship between board characteristics, concentrated ownership structure, shareholder activism, financial metrics identified as control variables, and sustainability scores was evaluated via robust random effects (static) and System Generalized Method of Moments (System GMM) (dynamic) panel data estimators. According to the static estimation results, board meeting frequency and the ratio of female members serve as positive drivers for sustainability transparency. In the dynamic model estimates, these governance mechanisms lose their explanatory power and show no statistically observable effect. However, across both methodological approaches, firm size, which was integrated as a control factor, consistently demonstrates a robust positive correlation with levels of disclosure. These findings reveal that governance mechanisms such as the percentage of female members and meeting frequency have a short-term and marginal effect, but structural factors such as company size are the main determinants for a long-term and sustainable level of transparency in Türkiye. Consequently, market regulators should deploy policy frameworks that incentivize disclosure trajectories aligned with international frameworks while fostering voluntary reporting. Concurrently, corporate managers should look beyond mere statutory compliance and continuously embrace extensive global reporting standards. Full article

This study examines the relationship between governance quality and carbon intensity in Saudi Arabia over the period 2002–2024, with particular attention to the role of structural reform and institutional change. Using an autoregressive distributed lag (ARDL) framework, the analysis distinguishes between long-run equilibrium relationships and short-run adjustment dynamics in a resource-dependent economy undergoing economic transition. The long-run results indicate that capital formation significantly increases carbon intensity, suggesting that economic expansion and investment activities remain closely tied to carbon-intensive production structures and fossil-based industrial development. Renewable energy exhibits a modest mitigating effect, implying that recent progress in energy diversification has contributed to emissions efficiency, although its overall impact remains limited relative to the scale of hydrocarbon dependence. Governance does not display a robust independent long-run effect on carbon intensity. However, the interaction between governance and the post-2016 reform period is associated with lower carbon intensity, indicating that institutional quality becomes more effective when supported by broader structural transformation and policy reform initiatives. Short-run dynamics further suggest that improvements in governance may initially coincide with higher emissions intensity during transitional phases of economic adjustment and infrastructure expansion. The findings highlight that governance influences environmental performance not in isolation, but through its interaction with structural diversification, energy transition, and reform-oriented institutional change in a resource-dependent economy. Full article

Cancer progression is closely associated with dysregulation of apoptosis, enabling malignant cells to evade programmed cell death and develop resistance to therapy. Among the key regulators of this process, the tumor suppressor protein p53 and the Bcl-2 family of proteins play central and interconnected roles in controlling cell survival and mitochondrial integrity. In recent years, naturally occurring flavonoids have attracted considerable attention as potential modulators of these pathways due to their diverse biological activities and relatively low toxicity. This review provides a focused and integrative overview of how different subclasses of flavonoids modulate the p53–Bcl-2 signaling axis to regulate apoptosis in cancer cells. Particular emphasis is placed on the mechanistic interplay between p53 stabilization, transcriptional regulation of apoptotic targets, mitochondrial outer membrane permeabilization, and caspase activation. In contrast to previous general reviews on flavonoids and cancer, this work provides an integrated overview of evidence across multiple flavonoid subclasses and experimental cancer models, highlighting both shared and pathway-specific apoptotic responses. Experimental findings from in vitro and in vivo studies are discussed, including the effects of quercetin, kaempferol, myricetin, epigallocatechin gallate, and related compounds on cell-cycle arrest, oxidative stress, mitochondrial dysfunction, and intrinsic apoptotic signaling. Furthermore, the review examines the relationship between flavonoid chemical structure and biological activity, with particular attention to bioavailability, metabolic transformation, and strategies aimed at improving therapeutic efficacy, including structural modification and nanocarrier-based delivery systems. Despite promising preclinical findings, significant translational challenges remain, including poor pharmacokinetic properties, variability among experimental models, and limited clinical validation. Overall, flavonoids represent a promising class of bioactive compounds capable of targeting apoptosis through modulation of the p53–Bcl-2 network, and a deeper mechanistic understanding of their activity may support the development of novel targeted and combination anticancer therapies. Full article

Background/Objectives: Antimicrobial resistance and bacterial persistence underscore the need to develop new chemotypes with multifunctional antibacterial mechanisms. This study aimed to design, synthesize, and evaluate curcumin-inspired 3,5-diarylidene-4-piperidones as versatile small molecules exhibiting antibacterial, antibiofilm, anti-efflux, DNA gyrase-inhibitory, and antiproliferative properties. Methods: A targeted series of triazole-conjugated 3,5-diarylidene-4-piperidones was synthesized through copper-catalyzed azide-alkyne cycloaddition click chemistry and subsequently characterized using standard spectroscopic techniques. The compounds were assessed for antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli. Selected active compounds underwent further evaluation for DNA gyrase inhibition, antibiofilm activity against multidrug-resistant S. aureus ATCC 33591, ethidium bromide accumulation, and antiproliferative effects on HCT116 and MCF7 cancer cells, with RPE1 cells serving as a control to evaluate cytotoxicity in normal cells. Additionally, computational studies, including QSAR analysis and molecular docking, were conducted to bolster structure–activity relationships and provide mechanistic insights. Results: Several derivatives demonstrated selective antibacterial activity against Gram-positive bacteria, particularly S. aureus, while exhibiting limited or no efficacy against E. coli. Compounds 7n and 7l emerged as the most potent against S. aureus, with minimum inhibitory concentrations (MICs) of 7.8 and 8.2 μM, respectively. Notably, compound 7l inhibited S. aureus DNA gyrase supercoiling, displaying an IC₅₀ of 3.20 μM, comparable to ciprofloxacin. Compound 7e exhibited the strongest antibiofilm activity against multidrug-resistant S. aureus, whereas compound 7a resulted in the highest accumulation of ethidium bromide, indicating robust anti-efflux activity. Antiproliferative assays revealed that select halogenated derivatives were effective against HCT116 and MCF7 cells, while the most promising antibacterial compounds exhibited minimal cytotoxicity toward RPE1 cells. Quantitative structure–activity relationship (QSAR) and docking studies supported the observed structure–activity relationships and suggested potential interactions with the ATPase binding site of DNA gyrase B. Conclusions: Triazole-conjugated 3,5-diarylidene-4-piperidones are promising multifunctional scaffolds with selective anti-S. aureus activity, antibiofilm and anti-efflux properties, and, for compound 7l, potent DNA gyrase inhibition. These findings support further optimization of this chemotype as a platform for developing antibacterial agents with polymechanistic activity. Full article

Background: The relationship between physical exercise and human longevity constitutes one of the most consequential intersections in contemporary preventive medicine. Although international guidelines recommend 150 min of moderate-intensity exercise weekly, growing evidence suggests that the architecture of optimal exercise is far more complex, encompassing dose, modality, timing across the lifespan, and the paradox risks imposed by extreme endurance. Methods: We included in this narrative review landmark cohort studies, randomized controlled trials, meta-analyses, and expert physiological frameworks published in high-impact cardiovascular, sports medicine, and longevity journals from 1966 to 2024. Results: Cardiorespiratory fitness (CRF), indexed by maximal oxygen uptake (VO₂ max), demonstrates the strongest and most linear dose–response relationship with all-cause mortality identified in preventive medicine, with every 1 metabolic equivalent of task (MET) increment associated with a 12–15% reduction in mortality risk. The optimal dose of vigorous-intensity exercise follows a J-shaped dose–response curve: 3–5 sessions per week generating 1–2.4 h of vigorous activity is associated with the lowest all-cause mortality risk in large prospective cohorts, whereas chronic extreme endurance exercise incurs measurable atrial remodeling, patchy myocardial fibrosis, and a 5.3-fold increase in the risk of atrial fibrillation. The importance of exercise types shifts profoundly across the lifespan, transitioning from aerobic capacity effort in the third decade to resistance training in the seventh decade and neuromuscular stability in the eighth. Based on our interpretation of the available evidence, we propose a structured, personalized four-step exercise pathway integrating CRF assessment, lifespan-adapted prescription, lifestyle co-interventions, and periodic reassessment. Conclusions: Among currently available lifestyle interventions, regular exercise is consistently associated with some of the largest and most reproducible reductions in all-cause and cardiovascular mortality observed in prospective cohort data, while remaining accessible and cost-effective. Full article

Bismuth tungstate (Bi₂WO₆) is a typical bismuth-based visible-light-responsive semiconductor photocatalyst that has attracted significant attention in the fields of environment remediation and energy conversion. In this paper, to address the issues of high photogenerated carrier recombination rate and limited visible-light-response range of Bi₂WO₆, various modification strategies are highlighted, including morphology control, element doping, heterojunction construction, carbon material compositing, and coupling with functional materials such as metal–organic frameworks (MOFs), covalent organic frameworks (COFs), or conductive polymers. Furthermore, the structure–activity relationships are discussed. On this basis, the latest application progress of Bi₂WO₆-based photocatalysts in fields such as pollutant degradation, antibacterial activity, and energy conversion and storage is summarized. Finally, prospects are put forward regarding the existing shortcomings and future development directions in the application of Bi₂WO₆-based photocatalysts, aiming to provide a systematic theoretical reference for the design and application of high-performance Bi₂WO₆-based photocatalysts. Full article

Scorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology. However, recent studies have revealed their potential for regulating oxidative stress, inflammation, and neuroprotection, making them a new research frontier. In this article, we focus on scorpion venom peptides as drugs, constructing an integrated knowledge framework from structural classification to clinical translation. First, scorpion venom peptides are systematically classified based on cysteine arrangement patterns and three-dimensional folding topology, and their structure–activity relationships are summarized. Based on this, the molecular mechanisms by which scorpion venom peptides regulate ion channels are systematically analyzed. We review the emerging pharmacological activities of scorpion venom peptides. Of particular note, the representative molecule SVHRSP has shown multi-target synergistic antioxidant and neuroprotective activity in models of Parkinson’s disease. We also systematically evaluate the application of engineering strategies, including cyclisation modification, nanodelivery, recombinant expression, and AI-assisted optimization, to overcome the translational bottlenecks in the development of scorpion venom peptides. However, it should be noted that most SVHRSP-related findings have been reported by a single research group; independent replication, pharmacokinetic characterization, and human efficacy data are still lacking. Its IND approval permits clinical investigation but does not yet constitute proven therapeutic benefit in patients. By integrating molecular structure, redox regulation mechanisms, and translational medicine perspectives, this review aims at providing a theoretical basis and practical pathways for scorpion venom peptides as precision therapeutic molecules for oxidative stress-related diseases. Full article

ESG-oriented marketing and its influence on consumers’ green consumption behavior have become important issues in sustainable development research, yet the emotional and cognitive mechanisms underlying this relationship remain insufficiently examined. Drawing on an integrated emotion–cognition–behavior perspective, this study focuses on Chinese Generation Z consumers and develops a model linking Perceived ESG Communication, Eco-Anxiety, Perceived Consumer Effectiveness, and Green Action Intention. Based on 400 valid survey responses, structural equation modeling and PROCESS 4.1 were employed to examine the structural relationships, mediation effects, and serial mediation pathway among the focal constructs. The results show that Perceived ESG Communication is positively associated with Green Action Intention both directly and indirectly. Specifically, Eco-Anxiety and Perceived Consumer Effectiveness each serve as significant mediators in the relationship between Perceived ESG Communication and Green Action Intention. Further analysis indicates that Eco-Anxiety is positively associated with Perceived Consumer Effectiveness, forming a significant serial mediation pathway through which ESG-related communication is linked to green action intention. These findings suggest that ESG-oriented marketing may influence Generation Z consumers not only by transmitting sustainability-related information, but also by activating environmental concern and strengthening consumers’ perceived effectiveness in contributing to sustainability outcomes. The study contributes to ESG communication and sustainable consumption research by clarifying the affective and cognitive mechanisms through which perceived ESG messages become behaviorally meaningful for young consumers. It also provides practical implications for designing ESG-oriented marketing strategies that combine credible responsibility communication with clear consumer action pathways. Full article

Increasing attention has been directed toward walkability evaluation because pedestrian environments are closely associated with mobility patterns, environmental quality, and everyday spatial experience. However, most existing walkability studies either emphasize objective spatial indicators or rely on subjective satisfaction surveys, while the relationship between expert evaluation and user satisfaction has received relatively limited attention, particularly regarding its nonlinear characteristics. In addition, walkability frameworks developed for urban public environments are often directly applied to university campuses without adequately considering the distinctive behavioral characteristics of campus pedestrian activities. To address these limitations, this study proposes an integrated AHP–Kano walkability evaluation framework for campus pedestrian systems. The framework combines the Analytic Hierarchy Process (AHP) with the Kano model to establish a perception-sensitive and behavior-oriented evaluation structure. AHP is employed to determine the relative importance of environmental indicators through expert judgment, while the Kano model is introduced to capture the asymmetric effects of different environmental attributes on user satisfaction. GIS analysis and field investigation were employed as supplementary spatial diagnostic tools to support the interpretation of pedestrian–environment characteristics. Using the Xiamen campus of Huaqiao University as a case study, this research constructs a multidimensional evaluation system covering accessibility, safety, comfort, landscape quality, and service functionality. Questionnaire surveys and expert evaluations were conducted to analyze the relationship between objective environmental importance and subjective perceptual response. The results indicate that safety- and accessibility-related attributes primarily function as must-be requirements that prevent dissatisfaction, whereas environmental cleanliness and selected experiential elements exhibit stronger satisfaction-enhancing effects. Several landscape-related indicators, commonly emphasized in urban walkability studies, demonstrate relatively weak perceptual sensitivity in campus contexts, reflecting the task-oriented and time-constrained nature of campus pedestrian behavior. The present study extends existing walkability research in several important respects. Rather than relying on conventional linear assumptions, the proposed framework incorporates nonlinear perceptual responses into walkability evaluation. The findings further demonstrate that pedestrian perception is highly context-dependent in campus environments, while the integrated framework further provides a behavior-sensitive basis for prioritizing spatial interventions. Full article

Mediterranean regions are forecasted to be increasingly threatened by climate change, leading to the occurrence of extreme events. One strategy to improve the resilience of agricultural systems is to introduce rotations that combine legumes and crops with high intraspecific diversity such as evolutionary populations (EPs). These cropping systems may be characterized by lower external input needs and higher buffering capacity than traditional ones. Our objective was to test if the introduction of wheat EPs impacts soil microbial functions—including microbial biomass, community structure, and enzymatic activity—and soil organic matter composition within a crop rotation framework. We conducted a two-year field experiment at two sites in Italy comparing a modern bread wheat variety to two EPs, evolved in different areas, in rotation with legumes. The composition and processes of rhizosphere microbial communities were characterized using EL-FAME and enzyme activities. In addition, rhizosphere soil organic matter signatures were measured by mid-infrared spectroscopy, and their relationships with microbial parameters were investigated using principal component analyses. The results showed that the EP–rhizosphere relationship, as well as its influence on microbial abundance and activity, is dependent both on the site of origin and local pedoclimatic conditions, although no consistent response was observed across the two sites. These effects may be buffered by the choice of the preceding crop in rotation. Full article

The successful application of extrusion-based 3D-printed geopolymer mortars largely depends on precursor chemistry, activator composition, mixture proportions, and fresh-state behavior, which is highly sensitive to time-dependent structural build-up. This review examines the relationships among mix design, geopolymerization chemistry, rheological properties, and printability requirements for 3D-printed geopolymer mortars. Particular emphasis is placed on the effects of precursor type, alkaline activator characteristics, liquid-to-solid ratio, additives, and fibers on flowability, yield stress, viscosity, extrudability, buildability, shape retention, and interlayer bonding. The review further discusses how geopolymerization kinetics influence the evolution of fresh-state properties, the printable time window, and the transition from extrusion to structural stability. In addition, early-age performance is evaluated in terms of setting behavior, green strength development, and layer-interface integrity. Current challenges, including the lack of standardized test methods, limited comparability among published studies, and the complex coupling between material design and process parameters, are also highlighted. Finally, the review identifies key research gaps and proposes future directions for developing robust, printable, and sustainable geopolymer mortar systems for additive manufacturing in construction. Full article

Background: Psychological distress (PD) has been associated with lifestyle behaviors, including physical activity, sleep duration, and diet-related practices. Dietary self-efficacy may represent a self-regulatory correlate in these relationships; however, evidence from population studies remains limited, particularly in Peruvian adults. Objective: To examine whether dietary self-efficacy is statistically associated with the links between physical activity, sleep duration, vegetarian status, and PD in a sample of Peruvian adults. Methods: A cross-sectional study was conducted in 684 Peruvian adults. Structural equation modeling (SEM) was used to evaluate the proposed associations, adjusting for age, sex, educational level, marital status, residence, and BMI. Results: The SEM showed acceptable fit, with RMSEA and SRMR within recommended ranges and CFI/TLI slightly below 0.90 (CFI = 0.898, TLI = 0.886, RMSEA = 0.039, SRMR = 0.047). Lower dietary self-efficacy was associated with higher PD (β = 0.283, p < 0.001). Physical activity showed an indirect statistical association with lower PD via dietary self-efficacy (β = −0.043, p < 0.001) and a significant total association with PD (β = −0.085, p = 0.018). Sleep duration showed a curvilinear (U-shaped) association with PD (linear β = −0.122, p = 0.001; quadratic β = 0.124, p < 0.001), but not via dietary self-efficacy. Vegetarian status was not directly associated with PD (β = 0.002, p = 0.956), and its indirect statistical association via dietary self-efficacy did not reach conventional significance (β = 0.022, p = 0.070). The model explained 14.1% of the variance in dietary self-efficacy and 19.3% of the variance in PD. Conclusions: Lower dietary self-efficacy was associated with higher PD and captured a model-based indirect statistical association between physical activity and PD. Given the cross-sectional design, these findings should be interpreted as correlational and warrant confirmation in longitudinal or experimental studies. Full article

The role of financial institutions in climate governance is increasingly being recognized, particularly in relation to Scope 3 emissions. While existing research has focused primarily on lending and investment activities, the potential influence of insurance operations on lifecycle emissions remains underexplored. This study examines electric vehicle (EV) insurance underwriting as a form of indirect climate governance, with particular attention being paid to claim-related decision processes that affect repair-, replacement-, and battery-related outcomes. A decision-analytical, scenario-based portfolio model is developed to analyze how underwriting and claims parameters may influence lifecycle emissions exposure. The model incorporates literature-informed and scenario-based parameter ranges derived from the lifecycle assessment literature and industry-relevant assumptions, while explicitly accounting for regulatory, technical, and behavioral constraints that limit insurer decision making. An exposure-based attribution framework is applied to link insurance-mediated outcomes to emissions associated with vehicle and battery manufacturing. The results suggest that claim-related parameters—particularly total-loss probability—are associated with variations in modeled emissions exposure within the analytical framework. Scenario analysis indicates that, under plausible parameter configurations, differences in claims decision structures may contribute to variation in lifecycle emissions at the portfolio level. Sensitivity analysis further indicates that these relationships appear stable across a range of parameter assumptions. The findings should be interpreted as scenario-based insights rather than empirical estimates, highlighting potential pathways through which insurance operations may influence emissions outcomes within existing constraints. The study contributes to the literature by extending Scope 3 governance analysis to insurance and by proposing an operational framework for interpreting insurance-associated emissions in lifecycle terms. Full article