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Antibiotics
Volume 9
Issue 11
10.3390/antibiotics9110797
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Open AccessArticle

Towards the Identification of Antibiotic-Resistant Bacteria Causing Urinary Tract Infections Using Volatile Organic Compounds Analysis—A Pilot Study

by
Keith Hewett
1,†,
Natalia Drabińska
1,2,*,†,
Paul White
3,
Matthew B. Avison
4,
Raj Persad
5,
Norman Ratcliffe
1 and
Ben de Lacy Costello
1,*
1
Department of Applied Sciences, Faculty of Health and Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK
2
Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, 10-748 Olsztyn, Poland
3
Applied Statistics Group, Department of Engineering, Design and Mathematics, Faculty of Environment and Technology, University of the West of England, Bristol BS16 1QY, UK
4
School of Cellular & Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol BS8 1TD, UK
5
Bristol Royal Infirmary and Bristol Urological Institute, Southmead Hospital, Bristol BS10 5BN, UK
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antibiotics 2020, 9(11), 797; https://doi.org/10.3390/antibiotics9110797
Received: 28 September 2020 / Revised: 8 November 2020 / Accepted: 10 November 2020 / Published: 11 November 2020
(This article belongs to the Special Issue Metabolic Profiling for Microbial Resistance)
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Abstract

Antibiotic resistance is an unprecedented threat to modern medicine. The analysis of volatile organic compounds (VOCs) from bacteria potentially offers a rapid way to determine antibiotic susceptibility in bacteria. This study aimed to find the optimal conditions to obtain the maximum number of VOCs detected which next allowed the assessment of differences in VOC profiles between susceptible and resistant isolates of Escherichia coli causing urinary tract infections. The analysis of VOCs in the headspace above the bacterial cultures allowed the distinguishing of resistant and susceptible bacteria based on the abundance of six VOCs with 85.7% overall accuracy. The results of this preliminary study are promising, and with development could lead to a practical, faster diagnostic method for use in routine microbiology. View Full-Text
Keywords: volatile; metabolite; profiles; gas chromatography-mass spectrometry; antibiotic resistance; bacteria; urinary tract infection; susceptibility; E. coli volatile; metabolite; profiles; gas chromatography-mass spectrometry; antibiotic resistance; bacteria; urinary tract infection; susceptibility; E. coli
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MDPI and ACS Style

Hewett, K.; Drabińska, N.; White, P.; Avison, M.B.; Persad, R.; Ratcliffe, N.; Costello, B.d.L. Towards the Identification of Antibiotic-Resistant Bacteria Causing Urinary Tract Infections Using Volatile Organic Compounds Analysis—A Pilot Study. Antibiotics 2020, 9, 797.

AMA Style

Hewett K, Drabińska N, White P, Avison MB, Persad R, Ratcliffe N, Costello BdL. Towards the Identification of Antibiotic-Resistant Bacteria Causing Urinary Tract Infections Using Volatile Organic Compounds Analysis—A Pilot Study. Antibiotics. 2020; 9(11):797.

Chicago/Turabian Style

Hewett, Keith; Drabińska, Natalia; White, Paul; Avison, Matthew B.; Persad, Raj; Ratcliffe, Norman; Costello, Ben d.L. 2020. "Towards the Identification of Antibiotic-Resistant Bacteria Causing Urinary Tract Infections Using Volatile Organic Compounds Analysis—A Pilot Study" Antibiotics 9, no. 11: 797.

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