A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019
Abstract
1. Introduction
2. Results
2.1. Clinical Characteristics and Manifestations
2.2. Microbiology
2.3. Treatment and Outcome
3. Discussion
4. Materials and Methods
4.1. Samples
4.2. Laboratory Investigations
4.3. Molecular Identification Using ITS-Sequencing and STR-Genotyping
4.4. Antifungal Susceptibility Testing
4.5. Ethical Statement
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample No | MALDI-TOF/Sequencing | Age/Year | Sex | Duration of Treatment (Days) | Time of Candidemia Post Admission (Weeks) | MIC Values (mg/L) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMB | FLC | ITC | VOR | POS | ISA | ANI | MICA | ||||||
317062126 | C. auris | 54 | M | 16 | 3 | 1 | >64 | 0.125 | 0.5 | 0.063 | 0.063 | 0.125 | 0.125 |
318005583 | C. auris | 50 | M | 28 | 2 | 1 | >64 | 0.125 | 0.5 | 0.063 | 0.031 | 0.5 | 0.25 |
317078724 | C. auris | 78 | F | 24 | 12 | 2 | 32 | 0.25 | 1 | 0.016 | 0.5 | 0.25 | 0.25 |
317052804 | C. auris | 69 | M | 14 | 1 | 0.5 | 64 | 0.063 | 0.25 | 0.016 | 0.125 | 0.25 | 0.125 |
318014168 | C. auris | 63 | F | 14 | 8 | 1 | 32 | 0.063 | 0.5 | 0.063 | 0.5 | 0.125 | 0.25 |
318014517 | C. auris | 30 | M | 4 | NA | 1 | 64 | 0.031 | 1 | 0.031 | 0.063 | 0.5 | 0.25 |
318028905 | C. auris | 76 | F | 10 | 16 | 1 | >64 | 0.125 | 1 | 0.063 | 0.031 | 0.25 | 0.25 |
318043084 | C. auris | 2 | M | 16 | 1 | 1 | >64 | 0.125 | 0.5 | 0.063 | 0.5 | 0.125 | 0.125 |
318066628 | C. auris | 0.5 | M | 15 | 4 | 2 | 64 | 0.5 | 0.5 | 0.031 | 0.063 | 0.5 | 0.25 |
318071689 | C. auris | 83 | M | NA | NA | 0.5 | 32 | 0.25 | 1 | 0.125 | 0.031 | 0.5 | 0.125 |
318095154 | C. auris | 70 | F | 17 | 3 | 1 | 64 | 0.125 | 1 | 0.063 | 0.063 | 0.125 | 0.25 |
319008550 | C. auris | 54 | M | 30 | 9 | 2 | >64 | 0.25 | 0.5 | 0.063 | 0.125 | 0.25 | 0.125 |
319056035 | C. auris | 62 | M | 2 | 2 | 2 | >64 | 0.063 | 0.5 | 0.063 | 0.25 | 0.125 | 0.125 |
320000205 | C. auris | 51 | M | 14 | 3 | 1 | 32 | 0.031 | 0.5 | 0.016 | 0.25 | 0.5 | 0.25 |
319087097 | C. auris | 62 | M | 2 | 5 | 1 | 64 | 0.125 | 1 | 0.031 | 0.063 | 0.5 | 0.25 |
319025492 | C. auris | 50 | M | 48 | 15 | 0.5 | >64 | 0.125 | 0.5 | 0.016 | 0.016 | 0.5 | 0.125 |
319033618 | C. auris | 47 | F | 16 | 2 | 1 | 32 | 0.125 | 0.25 | 0.016 | 0.016 | 0.5 | 0.25 |
319023375 | C. auris | 62 | M | 14 | 15 | 2 | >64 | 0.25 | 0.5 | 0.063 | 0.125 | 0.25 | 0.25 |
319089395 | C. auris | 49 | F | 11 | 5 | 1 | 32 | 0.063 | 0.5 | 0.016 | 0.125 | 0.5 | 0.25 |
319091222 | C. auris | 54 | M | 14 | 6 | 1 | 64 | 0.063 | 1 | 0.25 | 0.031 | 0.25 | 0.125 |
320005972 | C. auris | 31 | M | 14 | 1 | 1 | >64 | 0.5 | 1 | 0.125 | 0.5 | 0.25 | 0.125 |
319094383 | C. auris | 47 | M | 14 | 2 | 1 | 64 | 0.125 | 1 | 0.031 | 0.031 | 0.25 | 0.125 |
319029987 | C. auris | 64 | F | 17 | 2 | 1 | 64 | 0.125 | 1 | 0.25 | 0.031 | 0.25 | 0.125 |
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Mohsin, J.; Weerakoon, S.; Ahmed, S.; Puts, Y.; Al Balushi, Z.; Meis, J.F.; Al-Hatmi, A.M.S. A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019. Antibiotics 2020, 9, 638. https://doi.org/10.3390/antibiotics9100638
Mohsin J, Weerakoon S, Ahmed S, Puts Y, Al Balushi Z, Meis JF, Al-Hatmi AMS. A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019. Antibiotics. 2020; 9(10):638. https://doi.org/10.3390/antibiotics9100638
Chicago/Turabian StyleMohsin, Jalila, Sanjeewani Weerakoon, Sarah Ahmed, Ynze Puts, Zainab Al Balushi, Jacques F. Meis, and Abdullah M.S. Al-Hatmi. 2020. "A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019" Antibiotics 9, no. 10: 638. https://doi.org/10.3390/antibiotics9100638
APA StyleMohsin, J., Weerakoon, S., Ahmed, S., Puts, Y., Al Balushi, Z., Meis, J. F., & Al-Hatmi, A. M. S. (2020). A Cluster of Candida auris Blood Stream Infections in a Tertiary Care Hospital in Oman from 2016 to 2019. Antibiotics, 9(10), 638. https://doi.org/10.3390/antibiotics9100638