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Novel Aspects of Polynucleotide Phosphorylase Function in Streptomyces

Department of Biology, Emory University, Atlanta, GA 30322, USA
Antibiotics 2018, 7(1), 25; https://doi.org/10.3390/antibiotics7010025
Received: 14 February 2018 / Revised: 13 March 2018 / Accepted: 16 March 2018 / Published: 18 March 2018
(This article belongs to the Special Issue Actinomycetes: The Antibiotics Producers)
Polynucleotide phosphorylase (PNPase) is a 3′–5′-exoribnuclease that is found in most bacteria and in some eukaryotic organelles. The enzyme plays a key role in RNA decay in these systems. PNPase structure and function have been studied extensively in Escherichia coli, but there are several important aspects of PNPase function in Streptomyces that differ from what is observed in E. coli and other bacterial genera. This review highlights several of those differences: (1) the organization and expression of the PNPase gene in Streptomyces; (2) the possible function of PNPase as an RNA 3′-polyribonucleotide polymerase in Streptomyces; (3) the function of PNPase as both an exoribonuclease and as an RNA 3′-polyribonucleotide polymerase in Streptomyces; (4) the function of (p)ppGpp as a PNPase effector in Streptomyces. The review concludes with a consideration of a number of unanswered questions regarding the function of Streptomyces PNPase, which can be examined experimentally. View Full-Text
Keywords: polynucleotide phosphorylase; Streptomyces; ribonuclease; regulation; promoter; RNA decay; polyadenylation; (p)ppGpp; antibiotic polynucleotide phosphorylase; Streptomyces; ribonuclease; regulation; promoter; RNA decay; polyadenylation; (p)ppGpp; antibiotic
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Jones, G.H. Novel Aspects of Polynucleotide Phosphorylase Function in Streptomyces. Antibiotics 2018, 7, 25.

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