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Article

Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
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Author to whom correspondence should be addressed.
Academic Editor: Naresh Kumar
Antibiotics 2017, 6(1), 2; https://doi.org/10.3390/antibiotics6010002
Received: 6 December 2016 / Revised: 3 January 2017 / Accepted: 5 January 2017 / Published: 13 January 2017
(This article belongs to the Special Issue Antibiotic Synthesis)
Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity. View Full-Text
Keywords: antibacterial; tetramate; polyheterocycle; heteroaromatic; annulation antibacterial; tetramate; polyheterocycle; heteroaromatic; annulation
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MDPI and ACS Style

Chen, Y.; Moloney, J.G.; Christensen, K.E.; Moloney, M.G. Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity. Antibiotics 2017, 6, 2. https://doi.org/10.3390/antibiotics6010002

AMA Style

Chen Y, Moloney JG, Christensen KE, Moloney MG. Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity. Antibiotics. 2017; 6(1):2. https://doi.org/10.3390/antibiotics6010002

Chicago/Turabian Style

Chen, Yiyuan, Jonathan G. Moloney, Kirsten E. Christensen, and Mark G. Moloney 2017. "Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity" Antibiotics 6, no. 1: 2. https://doi.org/10.3390/antibiotics6010002

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