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Antibiotics 2017, 6(1), 2;

Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
Author to whom correspondence should be addressed.
Academic Editor: Naresh Kumar
Received: 6 December 2016 / Revised: 3 January 2017 / Accepted: 5 January 2017 / Published: 13 January 2017
(This article belongs to the Special Issue Antibiotic Synthesis)
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Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity. View Full-Text
Keywords: antibacterial; tetramate; polyheterocycle; heteroaromatic; annulation antibacterial; tetramate; polyheterocycle; heteroaromatic; annulation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, Y.; Moloney, J.G.; Christensen, K.E.; Moloney, M.G. Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity. Antibiotics 2017, 6, 2.

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