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Article

Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections

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LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal
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ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal
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CIQUP—Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
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DEQ—Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal
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CITAB—Centre for the Research and Technology for Agro-Environment and Biological Sciences, University of Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal
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Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal
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Author to whom correspondence should be addressed.
Academic Editor: Marc Maresca
Antibiotics 2022, 11(5), 620; https://doi.org/10.3390/antibiotics11050620
Received: 6 April 2022 / Revised: 2 May 2022 / Accepted: 2 May 2022 / Published: 4 May 2022
Diabetic foot ulcers (DFUs) are a common result of a complex secondary complication of diabetes mellitus. More than half of DFUs become infected due to frequent colonization with Staphylococcus aureus. The use of topical antibiotics is proposed, especially in combination with natural adjuvants, to minimize the negative impacts caused by generalized use of systemic antibiotics. In this study, 13 different phytochemicals—namely chalcone, juglone, cinnamic acid, trigonelline, Furvina—and four nitrovinylfuran derivatives—guaiazulene, α-bisabolol, farnesol and nerolidol—were selected to be tested as antibiotic enhancers. After minimum inhibitory and bactericidal concentration (MIC and MBC) determination of each molecule against different strains of S. aureus, including clinical isolates from diabetic foot wounds (CECT 976, Xu212, SA 1199B, RN4220, MJMC102, MJMC109, MJMC110 and MJMC111), their potentiation effects on the antibiotics fusidic acid, mupirocin, gentamicin, oxacillin and methicillin were evaluated through the disc diffusion method. Farnesol at sub-MIC was able to restore the activity of methicillin and oxacillin on the MJMC102 and MJMC111 strains, as well as two MRSA clinical isolates, and potentiated the effect of the remaining antibiotics. The results obtained demonstrate the great potential for the topical application of phytochemicals and derivatives as antibiotic resistance modifier agents to combat multidrug resistance in bacterial wound infections. View Full-Text
Keywords: antibiotic adjuvants; combination; diabetic foot ulcers; phytochemicals and derivatives; Staphylococcus aureus; topical antibiotics antibiotic adjuvants; combination; diabetic foot ulcers; phytochemicals and derivatives; Staphylococcus aureus; topical antibiotics
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MDPI and ACS Style

Oliveira, D.; Borges, A.; Saavedra, M.J.; Borges, F.; Simões, M. Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections. Antibiotics 2022, 11, 620. https://doi.org/10.3390/antibiotics11050620

AMA Style

Oliveira D, Borges A, Saavedra MJ, Borges F, Simões M. Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections. Antibiotics. 2022; 11(5):620. https://doi.org/10.3390/antibiotics11050620

Chicago/Turabian Style

Oliveira, Diana, Anabela Borges, Maria J. Saavedra, Fernanda Borges, and Manuel Simões. 2022. "Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections" Antibiotics 11, no. 5: 620. https://doi.org/10.3390/antibiotics11050620

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