Genomic Changes within a Subset of IncI2 Plasmids Associated with Dissemination of mcr-1 Genes and Other Important Antimicrobial Resistance Determinants
Abstract
:1. Introduction
2. Results
2.1. Global IncI2 Diversity
2.2. Comparison of IncI2 Plasmids from USA Surveillance
3. Discussion
4. Materials and Methods
4.1. Phylogenetic Reconstruction of IncI2 Plasmids
4.2. Analysis of USA Plasmids
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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ISEScan | No AMR | mcr-1 | mcr-7.1_1 | aadA, dfrA | blaCMY-2_1 | blaCTX-M-132_1 | blaCTX-M-15_1 | blaCTX-M-199_1 | blaCTX-M-55_1 | blaCTX-M-64_1 | blaKPC-3, aac(6’)-Ib, aadA, blaOXA-9, blaTEM-1 | blaKPC-3, blaTEM-1 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
No IS found | 99 | 32 | - | - | - | - | - | - | - | - | - | - |
IS1 | - | 2 | - | - | - | - | - | - | - | - | - | - |
IS1, IS200/IS605 | - | 13 | - | - | - | - | - | - | - | - | - | - |
IS1, IS30, IS91 | - | 2 | - | - | - | - | - | - | - | - | - | - |
IS1, IS5 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS110, IS3, IS30 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS1182, IS21 | - | - | - | - | - | - | - | - | - | - | 3 | 2 |
IS1182, IS21, IS91 | - | - | - | - | - | - | - | - | - | - | 1 | - |
IS1380 | - | 3 | 1 | - | 13 | 2 | - | 1 | 6 | 3 | - | - |
IS1380, IS3, IS30 | - | 1 | - | - | - | - | - | - | 1 | - | - | - |
IS1380, IS3, IS91 | - | - | - | - | - | - | 1 | - | - | - | - | - |
IS1380, IS30 | - | 2 | - | - | - | - | - | - | 2 | - | - | - |
IS200/IS605 | 15 | 11 | - | - | - | - | - | - | - | - | - | - |
IS200/IS605, IS3 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS200/IS605, IS30 | 1 | 9 | - | - | - | - | - | - | - | - | - | - |
IS200/IS605, IS91 | 1 | 1 | - | - | - | - | - | - | - | - | - | - |
IS3 | 3 | 3 | - | 1 | - | - | - | - | - | - | - | - |
IS3, IS30 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS3, IS91 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS30 | 1 | 20 | - | - | - | - | - | - | - | - | - | - |
IS30, IS5 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS30, IS630 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS30, IS66 | - | 2 | - | - | - | - | - | - | - | - | - | - |
IS30, IS91 | - | 1 | - | - | - | - | - | - | - | - | - | - |
IS4 | - | 4 | - | - | - | - | - | - | - | - | - | - |
IS66 | 1 | 1 | - | - | - | - | - | - | - | - | - | - |
IS91 | - | 6 | - | - | - | - | - | - | - | - | - | - |
ISEScan Result | No AMR | mcr-1.1 | blaCMY-2 | blaKPC-3, aac(6′)-Ib, aadA, blaOXA-9, blaTEM-1 |
---|---|---|---|---|
No IS found | 84 | - | - | - |
IS1182, IS21 | - | - | - | 2 |
IS1380 | - | - | 1 | - |
IS200/IS605 | 8 | 2 | - | - |
IS200/IS605, IS30 | 1 | 3 | - | - |
IS200/IS605, IS91 | - | 1 | - | - |
IS3 | 2 | - | - | - |
IS30 | 1 | - | - | - |
IS66 | 1 | - | - | - |
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Ricker, N.; Chalmers, G.; Whalen, E.; Allen, H.K.; Meinersmann, R.J. Genomic Changes within a Subset of IncI2 Plasmids Associated with Dissemination of mcr-1 Genes and Other Important Antimicrobial Resistance Determinants. Antibiotics 2022, 11, 181. https://doi.org/10.3390/antibiotics11020181
Ricker N, Chalmers G, Whalen E, Allen HK, Meinersmann RJ. Genomic Changes within a Subset of IncI2 Plasmids Associated with Dissemination of mcr-1 Genes and Other Important Antimicrobial Resistance Determinants. Antibiotics. 2022; 11(2):181. https://doi.org/10.3390/antibiotics11020181
Chicago/Turabian StyleRicker, Nicole, Gabhan Chalmers, Elli Whalen, Heather K. Allen, and Richard J. Meinersmann. 2022. "Genomic Changes within a Subset of IncI2 Plasmids Associated with Dissemination of mcr-1 Genes and Other Important Antimicrobial Resistance Determinants" Antibiotics 11, no. 2: 181. https://doi.org/10.3390/antibiotics11020181
APA StyleRicker, N., Chalmers, G., Whalen, E., Allen, H. K., & Meinersmann, R. J. (2022). Genomic Changes within a Subset of IncI2 Plasmids Associated with Dissemination of mcr-1 Genes and Other Important Antimicrobial Resistance Determinants. Antibiotics, 11(2), 181. https://doi.org/10.3390/antibiotics11020181