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Antibiotics
Volume 10
Issue 5
10.3390/antibiotics10050568
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Article
Peer-Review Record

Antibiotic-Resistant Enterobacteriaceae in Wastewater of Abattoirs

Antibiotics 2021, 10(5), 568; https://doi.org/10.3390/antibiotics10050568
by Timo Homeier-Bachmann 1,*, Stefan E. Heiden 2, Phillip K. Lübcke 1,2, Lisa Bachmann 3, Jürgen A. Bohnert 4, Dirk Zimmermann 5 and Katharina Schaufler 2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Antibiotics 2021, 10(5), 568; https://doi.org/10.3390/antibiotics10050568
Submission received: 27 April 2021 / Revised: 8 May 2021 / Accepted: 9 May 2021 / Published: 12 May 2021
(This article belongs to the Special Issue Antimicrobial Resistance: From Farm to Fork)

Round 1

Reviewer 1 Report

The manuscript reports important findings about antibiotic-resistant Enterobacteriaceae in wastewater of abattoirs. It requires some revision before its acceptance for publication in Antibiotics.

Abstract

Line 12, As pathogens,

Line 13, as commensals,

Line 16, ESBL, please give full name at its first usage

Lines 18-20, its seems that the sentence is fragmentary.

Line 21, please only give full percentage values (no digits)

Introduction

Line 37, ESBLs are not enzymes, but they excrete enzymes which …

Results

Line 126 and several more times in the text, how is “intermediate” defined?

Discussion

Line 205, the patterns in Figure 1 (469 versus 471; 552 versus 553) look similar, but not identical

Materials and Methods

Line 360, 10 000-fold dilution?

Line 369, AST should be named in full at its first usage

Conclusions

Lines 433-434, … two respects: first, … and, thus, …

References

Please adhere to the formatting rules of the journal, e.g. year in bold, only volumes but no issues to indicate.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The study from Homeier-Bachmann is an interesting investigation into Enterobacteriaceae resistance from slaughterhouse samples. I have no major comments, and only minor corrections to suggest:

  1. ESBL definition (lines 37-39) is narrow
  2. Please include the catalog number for ‘sterile gauze’ as this is not common practice
  3. Please expand on the WGS methods, such as trimming parameters other metrics used for QC, contamination, and consensus
  4. A comparison of sequenced isolates to those previously published would be a nice addition
  5. The sentence in lines 201-204 is confusing - please shorten / reword as it is not clear what is being said.
  6. Figure 2 is poor quality and in parts illegible. A heat map would be a better representation of much of this data. At the minimum, text should not be blurry

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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