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Article

Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS)—Part II

1
Department of Urology, Tzaneio General Hospital, 18536 Piraeus, Greece
2
Department of Anesthesiology and Pain Management, Tzaneio General Hospital, 18536 Piraeus, Greece
3
Department of Urology, Pediatric Urology and Andrology, Justus-Liebig University of Giessen, 35392 Giessen, Germany
4
School of Medicine, Technical University of Munich, 81664 Munich, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Albert Figueras
Antibiotics 2021, 10(10), 1253; https://doi.org/10.3390/antibiotics10101253
Received: 6 September 2021 / Revised: 9 October 2021 / Accepted: 11 October 2021 / Published: 15 October 2021
(This article belongs to the Special Issue Difficult to Treat Infections in Urology)
The Acute Cystitis Symptom Score (ACSS) is a patient self-reporting questionnaire for the clinical diagnosis and patient-reported outcome (PRO) in women with acute uncomplicated cystitis (AC). The aim of the current study (part II) is the clinical validation of the Greek ACSS questionnaire. After linguistic validation according to internationally accepted guidelines and cognitive assessment (part I), the clinical validation was performed by using the Greek ACSS study version in 92 evaluable female participants including 53 patients with symptoms suspicious of AC and 39 controls. The clinical outcome using the ACSS questionnaire at different points in time after the start of treatment was demonstrated as well. The age (mean ± SD) of the 53 patients (44.7 ± 17.0 years) and 39 controls (49.3 ± 15.9 years) and their additional conditions at baseline visits, such as menstruation, premenstrual syndrome, pregnancy, menopause, diabetes mellitus, were comparable. There was, however, a significant difference (p < 0.001) between patients and controls at baseline visit regarding sum score of the ACSS domains, such as typical symptoms and quality of life. The clinical outcome of up to 7 days showed a fast reduction of the symptom scores and improvement of quality of life. The optimal thresholds for the patient-reported outcome of successful therapy could be established. The linguistically and clinically validated Greek ACSS questionnaire can now be used for clinical or epidemiological studies and also for patients’ self-diagnosis of AC and as a PRO measure tool. View Full-Text
Keywords: Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women
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MDPI and ACS Style

Stamatiou, K.; Samara, E.; Alidjanov, J.F.; Pilatz, A.M.E.; Naber, K.G.; Wagenlehner, F.M.E. Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS)—Part II. Antibiotics 2021, 10, 1253. https://doi.org/10.3390/antibiotics10101253

AMA Style

Stamatiou K, Samara E, Alidjanov JF, Pilatz AME, Naber KG, Wagenlehner FME. Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS)—Part II. Antibiotics. 2021; 10(10):1253. https://doi.org/10.3390/antibiotics10101253

Chicago/Turabian Style

Stamatiou, Konstantinos, Evangelia Samara, Jakhongir F. Alidjanov, Adrian M.E. Pilatz, Kurt G. Naber, and Florian M.E. Wagenlehner 2021. "Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS)—Part II" Antibiotics 10, no. 10: 1253. https://doi.org/10.3390/antibiotics10101253

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