Next Article in Journal
Development of MoSe2 Nano-Urchins as a Sensing Platform for a Selective Bio-Capturing of Escherichia coli Shiga Toxin DNA
Next Article in Special Issue
Rapid Nanofabrication of Nanostructured Interdigitated Electrodes (nIDEs) for Long-Term In Vitro Analysis of Human Induced Pluripotent Stem Cell Differentiated Cardiomyocytes
Previous Article in Journal
Computational Study of Sensitivity Enhancement in Surface Plasmon Resonance (SPR) Biosensors by Using the Inclusion of the Core-Shell for Biomaterial Sample Detection
Previous Article in Special Issue
Transistors for Chemical Monitoring of Living Cells
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessReview
Biosensors 2018, 8(3), 76; https://doi.org/10.3390/bios8030076

Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells

1
Division of Applied Mathematics, Brown University, Providence, RI 02912, USA
2
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
3
School of Engineering, Brown University, Providence, RI 02912, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 June 2018 / Revised: 31 July 2018 / Accepted: 6 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Cell-based Biosensors)
Full-Text   |   PDF [11611 KB, uploaded 10 August 2018]   |  

Abstract

In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins or changes to the extracellular environment, lead to compromised cell deformability, impaired cell stability, and increased propensity to aggregate. Numerous laboratory approaches have been implemented to elucidate the pathogenesis of RBC disorders. Concurrently, computational RBC models have been developed to simulate the dynamics of RBCs under physiological and pathological conditions. In this work, we review recent laboratory and computational studies of disordered RBCs. Distinguished from previous reviews, we emphasize how experimental techniques and computational modeling can be synergically integrated to improve the understanding of the pathophysiology of hematological disorders. View Full-Text
Keywords: red blood cell disorders; numerical modeling; laboratory approaches red blood cell disorders; numerical modeling; laboratory approaches
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Li, H.; Papageorgiou, D.P.; Chang, H.-Y.; Lu, L.; Yang, J.; Deng, Y. Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells. Biosensors 2018, 8, 76.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biosensors EISSN 2079-6374 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top