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Volume 13
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Article

Graphitic Carbon Nitride Nanoheterostructures as Novel Platforms for the Electrochemical Sensing of the Chemotherapeutic and Immunomodulator Agent MTX

by
Reham G. Elfarargy
,
Mahmoud A. Saleh
,
Mohamed Mahrous Abodouh
,
Mahmoud A. Hamza
and
Nageh K. Allam
*
Energy Materials Laboratory, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt
*
Author to whom correspondence should be addressed.
Biosensors 2023, 13(1), 51; https://doi.org/10.3390/bios13010051
Submission received: 24 October 2022 / Revised: 24 November 2022 / Accepted: 25 November 2022 / Published: 29 December 2022
(This article belongs to the Special Issue Advanced Functional Materials for Electrochemical Sensor and Biosensor Applications)
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Abstract

We report on the electrochemical determination of one the most effective and widely used chemotherapeutic, anti-inflammatory, and immunomodulator agents, methotrexate (MTX), using low-cost, green, and facile one-pot prepared graphitic carbon nitride (g-CN ) nanosheets. The g-CN nanosheets have been characterized utilizing Fourier transform infrared spectroscopy, X-ray diffraction(XRD), scanning electron microscopy(SEM), and density functional theory (DFT). In comparison to the bare carbon paste electrode (CPE), the g-CN -modified electrode showed a spectacular enhancement in the electrochemical oxidation and detection abilities of MTX. The proposed material exhibits very low limits of detection (12.45 nM) and quantification (41.5 nM), while possessing a wide linear range of 0.22–1.11 μM and 1.11–27.03 μM under optimized conditions at pH 7.0. Due to the ease of preparation of g-CN, it can be adopted for the cost-effective detection of MTX in industrial and clinical analyses.
Keywords: graphitic carbon nitride; electrochemical sensors; methotrexate; LOD; DFT graphitic carbon nitride; electrochemical sensors; methotrexate; LOD; DFT

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MDPI and ACS Style

Elfarargy, R.G.; Saleh, M.A.; Abodouh, M.M.; Hamza, M.A.; Allam, N.K. Graphitic Carbon Nitride Nanoheterostructures as Novel Platforms for the Electrochemical Sensing of the Chemotherapeutic and Immunomodulator Agent MTX. Biosensors 2023, 13, 51. https://doi.org/10.3390/bios13010051

AMA Style

Elfarargy RG, Saleh MA, Abodouh MM, Hamza MA, Allam NK. Graphitic Carbon Nitride Nanoheterostructures as Novel Platforms for the Electrochemical Sensing of the Chemotherapeutic and Immunomodulator Agent MTX. Biosensors. 2023; 13(1):51. https://doi.org/10.3390/bios13010051

Chicago/Turabian Style

Elfarargy, Reham G., Mahmoud A. Saleh, Mohamed Mahrous Abodouh, Mahmoud A. Hamza, and Nageh K. Allam. 2023. "Graphitic Carbon Nitride Nanoheterostructures as Novel Platforms for the Electrochemical Sensing of the Chemotherapeutic and Immunomodulator Agent MTX" Biosensors 13, no. 1: 51. https://doi.org/10.3390/bios13010051

APA Style

Elfarargy, R. G., Saleh, M. A., Abodouh, M. M., Hamza, M. A., & Allam, N. K. (2023). Graphitic Carbon Nitride Nanoheterostructures as Novel Platforms for the Electrochemical Sensing of the Chemotherapeutic and Immunomodulator Agent MTX. Biosensors, 13(1), 51. https://doi.org/10.3390/bios13010051

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