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The Emergence of Insect Odorant Receptor-Based Biosensors

1
Department of Entomology, the Hebrew University of Jerusalem, Rehovot 76100, Israel
2
Institute of Agricultural Engineering, Agricultural Research Organization, Volcani Center, Rishon LeZion 5025001, Israel
*
Author to whom correspondence should be addressed.
Biosensors 2020, 10(3), 26; https://doi.org/10.3390/bios10030026
Received: 27 December 2019 / Revised: 11 March 2020 / Accepted: 12 March 2020 / Published: 17 March 2020
The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance in the fields of medicine, agriculture and public health. Insect ORs offer intrinsic amplification where a single binding event is transduced into a measurable ionic current. Consequently, insect ORs have great potential as biorecognition elements in many sensor configurations. However, integrating these sensing components onto electronic transducers for the development of biosensors has been marginal due to several drawbacks, including their lipophilic nature, signal transduction mechanism and the limited number of known cognate receptor-ligand pairs. We review the current state of research in this emerging field and highlight the use of a group of indole-sensitive ORs (indolORs) from unexpected sources for the development of biosensors. View Full-Text
Keywords: odorant receptor (OR); volatile organic compound (VOC); biosensor; carbon nanotube field-effect transistor (CNT-FET); indole; skatole; bioelectronic nose odorant receptor (OR); volatile organic compound (VOC); biosensor; carbon nanotube field-effect transistor (CNT-FET); indole; skatole; bioelectronic nose
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MDPI and ACS Style

Bohbot, J.D.; Vernick, S. The Emergence of Insect Odorant Receptor-Based Biosensors. Biosensors 2020, 10, 26.

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