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Laser-Synthesized SERS Substrates as Sensors toward Therapeutic Drug Monitoring

1
Dipartimento di Chimica, Materiali e Ingegneria Chimica “G. Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
2
Dipartimento di Energia, Politecnico di Milano, Via Ponzio 34/3, 20133 Milano, Italy
3
Division of Neurophysiopathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy
4
Laboratorio di Patologia Clinica e Genetica Medica, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy
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Dipartimento di Scienze Matematiche e Informatiche, Scienze Fisiche e Scienze della Terra, Università di Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, Italy
6
CNR-IPCF, Istituto per i Processi Chimico-Fisici del CNR, V.le F. S. D’Alcontres 37, 98158 Messina, Italy
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(5), 677; https://doi.org/10.3390/nano9050677
Received: 12 March 2019 / Revised: 17 April 2019 / Accepted: 19 April 2019 / Published: 1 May 2019
(This article belongs to the Special Issue Synthesis and Modification of Nanostructured Thin Films)
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Abstract

The synthesis by pulsed laser ablation and the characterization of both the surface nanostructure and the optical properties of noble metal nanoparticle-based substrates used in Surface Enhanced Raman Spectroscopy are discussed with reference to application in the detection of anti-epileptic drugs. Results on two representative drugs, namely Carbamazepine and Perampanel, are critically addressed. View Full-Text
Keywords: noble metal nanoparticles; pulsed laser ablation; surface enhanced Raman spectroscopy; antiepileptic drugs noble metal nanoparticles; pulsed laser ablation; surface enhanced Raman spectroscopy; antiepileptic drugs
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Tommasini, M.; Zanchi, C.; Lucotti, A.; Bombelli, A.; Villa, N.S.; Casazza, M.; Ciusani, E.; de Grazia, U.; Santoro, M.; Fazio, E.; Neri, F.; Trusso, S.; Ossi, P.M. Laser-Synthesized SERS Substrates as Sensors toward Therapeutic Drug Monitoring. Nanomaterials 2019, 9, 677.

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