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Nanomaterials 2019, 9(3), 447; https://doi.org/10.3390/nano9030447

Optimization of ZnO Nanorod-Based Surface Enhanced Raman Scattering Substrates for Bio-Applications

1
Biomedical Engineering Research Center, Asan Medical Center, Seoul 05505, Korea
2
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
3
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
4
Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
5
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Korea
6
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea
7
Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 11 February 2019 / Revised: 6 March 2019 / Accepted: 14 March 2019 / Published: 17 March 2019
(This article belongs to the Special Issue Raman Imaging Methods for Nanomaterials and Bioapplications)
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Abstract

Nanorods based on ZnO for surface enhanced Raman spectroscopy are promising for the non-invasive and rapid detection of biomarkers and diagnosis of disease. However, optimization of nanorod and coating parameters is essential to their practical application. With the goal of establishing a baseline for early detection in biological applications, gold-coated ZnO nanorods were grown and coated to form porous structures. Prior to gold deposition, the grown nanorods were 30–50 nm in diameter and 500–600 nm in length. Gold coatings were grown on the nanorod structure to a series of thicknesses between 100 and 300 nm. A gold coating of 200 nm was found to optimize the Rhodamine B model analyte signal, while performance for rat urine depended on the biomarkers to be detected. These results establish design guidelines for future use of Au-ZnO nanorods in the study and early diagnosis of inflammatory diseases. View Full-Text
Keywords: gold coated thickness; ZnO nanorods; surface enhancement Raman spectroscopy (SERS); Au coated SERS; bladder disease detection gold coated thickness; ZnO nanorods; surface enhancement Raman spectroscopy (SERS); Au coated SERS; bladder disease detection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Jue, M.; Lee, S.; Paulson, B.; Namgoong, J.-M.; Yu, H.Y.; Kim, G.; Jeon, S.; Shin, D.-M.; Choo, M.-S.; Joo, J.; Moon, Y.; Pack, C.-G.; Kim, J.K. Optimization of ZnO Nanorod-Based Surface Enhanced Raman Scattering Substrates for Bio-Applications. Nanomaterials 2019, 9, 447.

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