Raman Imaging of Nanocarriers for Drug Delivery
AbstractThe efficacy of pharmaceutical agents can be greatly improved through nanocarrier delivery. Encapsulation of pharmaceutical agents into a nanocarrier can enhance their bioavailability and biocompatibility, whilst also facilitating targeted drug delivery to specific locations within the body. However, detailed understanding of the in vivo activity of the nanocarrier-drug conjugate is required prior to regulatory approval as a safe and effective treatment strategy. A comprehensive understanding of how nanocarriers travel to, and interact with, the intended target is required in order to optimize the dosing strategy, reduce potential off-target effects, and unwanted toxic effects. Raman spectroscopy has received much interest as a mechanism for label-free, non-invasive imaging of nanocarrier modes of action in vivo. Advanced Raman imaging techniques, including coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS), are paving the way for rigorous evaluation of nanocarrier activity at the single-cell level. This review focuses on the development of Raman imaging techniques to study organic nanocarrier delivery in cells and tissues. View Full-Text
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Vanden-Hehir, S.; Tipping, W.J.; Lee, M.; Brunton, V.G.; Williams, A.; Hulme, A.N. Raman Imaging of Nanocarriers for Drug Delivery. Nanomaterials 2019, 9, 341.
Vanden-Hehir S, Tipping WJ, Lee M, Brunton VG, Williams A, Hulme AN. Raman Imaging of Nanocarriers for Drug Delivery. Nanomaterials. 2019; 9(3):341.Chicago/Turabian Style
Vanden-Hehir, Sally; Tipping, William J.; Lee, Martin; Brunton, Valerie G.; Williams, Anna; Hulme, Alison N. 2019. "Raman Imaging of Nanocarriers for Drug Delivery." Nanomaterials 9, no. 3: 341.
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