Electrospun Filaments Embedding Bioactive Glass Particles with Ion Release and Enhanced Mineralization
by
Francesca Serio 1,2, Marta Miola 3, Enrica Vernè 3
, Dario Pisignano 4,5, Aldo R. Boccaccini 6 and Liliana Liverani 6,*
Francesca Serio 1,2, Marta Miola 3, Enrica Vernè 3, Dario Pisignano 4,5, Aldo R. Boccaccini 6 and Liliana Liverani 6,*
1
Dipartimento di Matematica e Fisica “Ennio De Giorgi,” Università del Salento, Via Arnesano, I-73100 Lecce, Italy
2
Istituto Microelettronica e Microsistemi-CNR, Via Monteroni, Campus Unisalento, I-73100 Lecce, Italy
3
Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, I-10129 Torino, Italy
4
Dipartimento di Fisica, Università di Pisa, Largo B. Pontecorvo 3, I-56127 Pisa, Italy
5
NEST, Istituto Nanoscienze-CNR, Piazza S. Silvestro 12, I-56127 Pisa, Italy
6
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, D-91058 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(2), 182; https://doi.org/10.3390/nano9020182
Received: 15 December 2018 / Revised: 25 January 2019 / Accepted: 28 January 2019 / Published: 1 February 2019
(This article belongs to the Special Issue Electrospun Nanofibers for Biomedical Applications)
Efforts in tissue engineering aim at creating scaffolds that mimic the physiological environment with its structural, topographical and mechanical properties for restoring the function of damaged tissue. In this study we introduce composite fibres made by a biodegradable poly(lactic acid) (PLLA) matrix embedding bioactive silica-based glass particles (SBA2). Electrospinning is performed to achieve porous PLLA filaments with uniform dispersion of bioactive glass powder. The obtained composite fibres show in aligned arrays significantly increased elastic modulus compared with that of neat polymer fibres during uniaxial tensile stress. Additionally, the SBA2 bioactivity is preserved upon encapsulation as highlighted by the promoted deposition of hydroxycarbonate apatite (HCA) upon immersion in simulated body fluid solutions. HCA formation is sequential to earlier processes of polymer erosion and ion release leading to acidification of the surrounding solution environment. These findings suggest PLLA-SBA2 fibres as a composite, multifunctional system which might be appealing for both bone and soft tissue engineering applications.
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MDPI and ACS Style
Serio, F.; Miola, M.; Vernè, E.; Pisignano, D.; Boccaccini, A.R.; Liverani, L. Electrospun Filaments Embedding Bioactive Glass Particles with Ion Release and Enhanced Mineralization. Nanomaterials 2019, 9, 182.
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