Next Article in Journal
Enhanced Efficiency of MAPbI3 Perovskite Solar Cells with FAPbX3 Perovskite Quantum Dots
Next Article in Special Issue
Electrospun Filaments Embedding Bioactive Glass Particles with Ion Release and Enhanced Mineralization
Previous Article in Journal
Computational Investigation of Tuning the Electron-Donating Ability in Metal-Free Organic Dyes Featuring an Azobenzene Spacer for Dye-Sensitized Solar Cells
Previous Article in Special Issue
Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective
Open AccessArticle

Fabrication of Gelatin Methacrylate (GelMA) Scaffolds with Nano- and Micro-Topographical and Morphological Features

Instituto de Investigaciones en Ciencia y Tecnología de Materiales, INTEMA (UNMdP-CONICET), Av. Juan B. Justo 4302, Mar del Plata B7608FDQ, Buenos Aires, Argentina
Instituto Nacional de Tecnología Industrial, Centro de Micro y Nanoelectrónica del Bicentenario (INTI-CMNB), Av. Gral. Paz 5445, San Martin B1650KNA, Buenos Aires, Argentina
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
Department of Materials Science and Engineering, Institute of Space Technology Islamabad, 1, Islamabad Highway, Islamabad 44000, Pakistan
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(1), 120;
Received: 12 December 2018 / Revised: 6 January 2019 / Accepted: 12 January 2019 / Published: 18 January 2019
(This article belongs to the Special Issue Electrospun Nanofibers for Biomedical Applications)
The design of biomimetic biomaterials for cell culture has become a great tool to study and understand cell behavior, tissue degradation, and lesion. Topographical and morphological features play an important role in modulating cell behavior. In this study, a dual methodology was evaluated to generate novel gelatin methacrylate (GelMA)-based scaffolds with nano and micro topographical and morphological features. First, electrospinning parameters and crosslinking processes were optimized to obtain electrospun nanofibrous scaffolds. GelMA mats were characterized by SEM, FTIR, DSC, TGA, contact angle, and water uptake. Various nanofibrous GelMA mats with defect-free fibers and stability in aqueous media were obtained. Then, micropatterned molds produced by photolithography were used as collectors in the electrospinning process. Thus, biocompatible GelMA nanofibrous scaffolds with micro-patterns that mimic extracellular matrix were obtained successfully by combining two micro/nanofabrication techniques, electrospinning, and micromolding. Taking into account the cell viability results, the methodology used in this study could be considered a valuable tool to develop patterned GelMA based nanofibrous scaffolds for cell culture and tissue engineering. View Full-Text
Keywords: biomimetic scaffolds; gelatin; electrospinning; micromolding; biomaterials biomimetic scaffolds; gelatin; electrospinning; micromolding; biomaterials
Show Figures

Graphical abstract

MDPI and ACS Style

Aldana, A.A.; Malatto, L.; Rehman, M.A.U.; Boccaccini, A.R.; Abraham, G.A. Fabrication of Gelatin Methacrylate (GelMA) Scaffolds with Nano- and Micro-Topographical and Morphological Features. Nanomaterials 2019, 9, 120.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop