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Nanomaterials 2019, 9(2), 184; https://doi.org/10.3390/nano9020184

Poly(vinylidene fluoride) Composite Nanofibers Containing Polyhedral Oligomeric Silsesquioxane–Epigallocatechin Gallate Conjugate for Bone Tissue Regeneration

1
Department of Biomedical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea
2
Department of Advanced Materials and Chemical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea
*
Author to whom correspondence should be addressed.
Received: 14 January 2019 / Revised: 23 January 2019 / Accepted: 29 January 2019 / Published: 1 February 2019
(This article belongs to the Special Issue Electrospun Nanofibers for Biomedical Applications)
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Abstract

To provide adequate conditions for the regeneration of damaged bone, it is necessary to develop piezoelectric porous membranes with antioxidant and anti-inflammatory activities. In this study, composite nanofibers comprising poly(vinylidene fluoride) (PVDF) and a polyhedral oligomeric silsesquioxane–epigallocatechin gallate (POSS–EGCG) conjugate were fabricated by electrospinning methods. The resulting composite nanofibers showed three-dimensionally interconnected porous structures. Their average diameters, ranging from 936 ± 223 nm to 1094 ± 394 nm, were hardly affected by the addition of the POSS–EGCG conjugate. On the other hand, the piezoelectric β-phase increased significantly from 77.4% to 88.1% after adding the POSS–EGCG conjugate. The mechanical strength of the composite nanofibers was ameliorated by the addition of the POSS–EGCG conjugate. The results of in vitro bioactivity tests exhibited that the proliferation and differentiation of osteoblasts (MC3T3-E1) on the nanofibers increased with the content of POSS–EGCG conjugate because of the improved piezoelectricity and antioxidant and anti-inflammatory properties of the nanofibers. All results could suggest that the PVDF composite nanofibers were effective for guided bone regeneration. View Full-Text
Keywords: bone regeneration; poly(vinylidene fluoride); composite nanofiber; piezoelectricity; antioxidant activity bone regeneration; poly(vinylidene fluoride); composite nanofiber; piezoelectricity; antioxidant activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Jeong, H.-G.; Han, Y.-S.; Jung, K.-H.; Kim, Y.-J. Poly(vinylidene fluoride) Composite Nanofibers Containing Polyhedral Oligomeric Silsesquioxane–Epigallocatechin Gallate Conjugate for Bone Tissue Regeneration. Nanomaterials 2019, 9, 184.

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