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Open AccessArticle

Biophysical Characterization of (Silica-coated) Cobalt Ferrite Nanoparticles for Hyperthermia Treatment

1
Institute of Physical Chemistry, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany
2
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Glückstraße 10a, 91054 Erlangen, Germany
3
Institute for Electrical Measurement Science and Fundamental Electrical Engineering, Technical University of Braunschweig, Hans-Sommer-Straße 66, 38106 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1713; https://doi.org/10.3390/nano9121713
Received: 11 November 2019 / Revised: 26 November 2019 / Accepted: 26 November 2019 / Published: 1 December 2019
(This article belongs to the Collection Applications of Magnetic Nanomaterials)
Magnetic hyperthermia is a technique that describes the heating of material through an external magnetic field. Classic hyperthermia is a medical condition where the human body overheats, being usually triggered by a heat stroke, which can lead to severe damage to organs and tissue due to the denaturation of cells. In modern medicine, hyperthermia can be deliberately induced to specified parts of the body to destroy malignant cells. Magnetic hyperthermia describes the way that this overheating is induced and it has the inherent advantage of being a minimal invasive method when compared to traditional surgery methods. This work presents a particle system that offers huge potential for hyperthermia treatments, given its good loss value, i.e., the particles dissipate a lot of heat to their surroundings when treated with an ac magnetic field. The measurements were performed in a low-cost custom hyperthermia setup. Additional toxicity assessments on Jurkat cells show a very low short-term toxicity on the particles and a moderate low toxicity after two days due to the prevalent health concerns towards nanoparticles in organisms. View Full-Text
Keywords: magnetism; hyperthermia; Induction; magnetic fluids; toxicity magnetism; hyperthermia; Induction; magnetic fluids; toxicity
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Lucht, N.; Friedrich, R.P.; Draack, S.; Alexiou, C.; Viereck, T.; Ludwig, F.; Hankiewicz, B. Biophysical Characterization of (Silica-coated) Cobalt Ferrite Nanoparticles for Hyperthermia Treatment. Nanomaterials 2019, 9, 1713.

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