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Open AccessArticle

Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration

1
Laboratory of Nanostructures, Institute of High Pressure Physics, Polish Academy of Sciences, 01142 Warsaw, Poland
2
Faculty of Materials Science and Engineering, Warsaw University of Technology, 02507 Warsaw, Poland
3
Laboratory for Biomimetic Membranes and Textiles, Empa Swiss Federal Laboratories for Materials Science and Technology, 9014 St. Gallen, Switzerland
4
Experimental Continuum Mechanics, Empa Swiss Federal Laboratories for Materials Science and Technology, 8600 Dübendorf, Switzerland
5
Department of Mechanical and Process Engineering, Institute for Mechanical Systems, ETH Zürich, 8092 Zürich, Switzerland
6
Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 03195 Warsaw, Poland
7
Department of Molecular Biology and Translational Research, Institute of Rural Health, 20090 Lublin, Poland
8
Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, 9014 St. Gallen, Switzerland
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1625; https://doi.org/10.3390/nano9111625
Received: 21 October 2019 / Revised: 12 November 2019 / Accepted: 13 November 2019 / Published: 15 November 2019
(This article belongs to the Special Issue Nanomaterials and Nanotechnology in Dentistry)
Diseases of periodontal tissues are a considerable clinical problem, connected with inflammatory processes and bone loss. The healing process often requires reconstruction of lost bone in the periodontal area. For that purpose, various membranes are used to prevent ingrowth of epithelium in the tissue defect and enhance bone regeneration. Currently-used membranes are mainly non-resorbable or are derived from animal tissues. Thus, there is an urgent need for non-animal-derived bioresorbable membranes with tuned resorption rates and porosity optimized for the circulation of body nutrients. We demonstrate membranes produced by the electrospinning of biodegradable polymers (PDLLA/PLGA) coated with nanohydroxyapatite (nHA). The nHA coating was made using two methods: sonocoating and electrospraying of nHA suspensions. In a simulated degradation study, for electrosprayed membranes, short-term calcium release was observed, followed by hydrolytic degradation. Sonocoating produced a well-adhering nHA layer with full coverage of the fibers. The layer slowed the polymer degradation and increased the membrane wettability. Due to gradual release of calcium ions the degradation-associated acidity of the polymer was neutralized. The sonocoated membranes exhibited good cellular metabolic activity responses against MG-63 and BJ cells. The collected results suggest their potential use in Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) periodontal procedures. View Full-Text
Keywords: electrospinning; sonocoating; electrospraying; periodontal regeneration; GTR/GBR membranes electrospinning; sonocoating; electrospraying; periodontal regeneration; GTR/GBR membranes
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MDPI and ACS Style

Higuchi, J.; Fortunato, G.; Woźniak, B.; Chodara, A.; Domaschke, S.; Męczyńska-Wielgosz, S.; Kruszewski, M.; Dommann, A.; Łojkowski, W. Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration. Nanomaterials 2019, 9, 1625. https://doi.org/10.3390/nano9111625

AMA Style

Higuchi J, Fortunato G, Woźniak B, Chodara A, Domaschke S, Męczyńska-Wielgosz S, Kruszewski M, Dommann A, Łojkowski W. Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration. Nanomaterials. 2019; 9(11):1625. https://doi.org/10.3390/nano9111625

Chicago/Turabian Style

Higuchi, Julia; Fortunato, Giuseppino; Woźniak, Bartosz; Chodara, Agnieszka; Domaschke, Sebastian; Męczyńska-Wielgosz, Sylwia; Kruszewski, Marcin; Dommann, Alex; Łojkowski, Witold. 2019. "Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration" Nanomaterials 9, no. 11: 1625. https://doi.org/10.3390/nano9111625

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