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Open AccessFeature PaperArticle

Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK
UCLan Research Centre for Smart Materials, School of Physical Sciences and Computing, University of Central Lancashire, Preston PR1 2HE, UK
Malvern Panalytical, Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ, UK
School of Chemistry, University of Manchester, Manchester M13 9PL, UK
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1563;
Received: 14 October 2019 / Revised: 28 October 2019 / Accepted: 28 October 2019 / Published: 4 November 2019
(This article belongs to the Special Issue Recent Progress in Antimicrobial Nanomaterials)
The study focuses on the development of a new family of layer-by-layer coatings comprising Nafion, lysozyme and chitosan to address challenges related to microbial contamination. Circular dichroism was employed to gain insights on the interactions of the building blocks at the molecular level. Quartz crystal microbalance tests were used to monitor in real time the build-up of multilayer coatings, while atomic force microscopy, contact angle and surface zeta potential measurements were performed to assess the surface characteristics of the multilayer assemblies. Remarkably, the nanocoated surfaces show almost 100% reduction in the population of both Escherichia coli and Staphylococcus aureus. The study suggests that Nafion based synergistic platforms can offer an effective line of defence against bacteria, facilitating antimicrobial mechanisms that go beyond the concept of exclusion zone. View Full-Text
Keywords: antimicrobial; layer-by-layer; coatings; Nafion; multilayers antimicrobial; layer-by-layer; coatings; Nafion; multilayers
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MDPI and ACS Style

Gibbons, E.N.; Winder, C.; Barron, E.; Fernandes, D.; Krysmann, M.J.; Kelarakis, A.; Parry, A.V.S.; Yeates, S.G. Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan. Nanomaterials 2019, 9, 1563.

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