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Nanomaterials 2018, 8(11), 935;

Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications

Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genova, Italy
Department of Applied Physics, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain
Excellence Research Unit “Modeling Nature” (MNat), University of Granada, 18016 Granada, Spain
Department of Human Anatomy and Embryology, University of Granada, 18016 Granada, Spain
Biopathology and Medicine Regenerative Institute (IBIMER), University of Granada, 18016 Granada, Spain
Biosanitary Institute of Granada (ibs.GRANADA), SAS-Universidad de Granada, 18016 Granada, Spain
Author to whom correspondence should be addressed.
Received: 9 October 2018 / Revised: 6 November 2018 / Accepted: 9 November 2018 / Published: 13 November 2018
(This article belongs to the Special Issue Nanomaterials for Photothermal/Photodynamic Therapy)
PDF [6164 KB, uploaded 13 November 2018]


Progress in nanotechnology has enabled us to open many new fronts in biomedical research by exploiting the peculiar properties of materials at the nanoscale. The thermal sensitivity of certain materials is a highly valuable property because it can be exploited in many promising applications, such as thermo-sensitive drug or gene delivery systems, thermotherapy, thermal biosensors, imaging, and diagnosis. This review focuses on recent advances in thermo-sensitive nanomaterials of interest in biomedical applications. We provide an overview of the different kinds of thermoresponsive nanomaterials, discussing their potential and the physical mechanisms behind their thermal response. We thoroughly review their applications in biomedicine and finally discuss the current challenges and future perspectives of thermal therapies. View Full-Text
Keywords: thermo-sensitive nanomaterials; PNIPAm; thermo-responsive polymers; LCST; thermochromism thermo-sensitive nanomaterials; PNIPAm; thermo-responsive polymers; LCST; thermochromism

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sánchez-Moreno, P.; De Vicente, J.; Nardecchia, S.; Marchal, J.A.; Boulaiz, H. Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications. Nanomaterials 2018, 8, 935.

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