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Article

Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration

by
Gustavo Richter Vaz
1,
Mariana Corrêa Falkembach Carrasco
1,
Matheus Monteiro Batista
1,
Paula Alice Bezerra Barros
1,
Meliza da Conceição Oliveira
1,
Ana Luiza Muccillo-Baisch
1,
Virginia Campello Yurgel
1,
Francesca Buttini
2,
Félix Alexandre Antunes Soares
3,
Larissa Marafiga Cordeiro
3,
Flavia Fachel
4,
Helder Ferreira Teixeira
4,
Juliana Bidone
5,
Patrícia Diaz de Oliveira
6,
Fabio Sonvico
2 and
Cristiana Lima Dora
1,*
1
Graduate Program in Health Sciences, Federal University of Rio Grande, Rio Grande 96203-900, Brazil
2
Food and Drug Department, University of Parma, 43124 Parma, Italy
3
Graduate Program in Biological Sciences, Federal University of Santa Maria, Santa Maria 97105-900, Brazil
4
Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-000, Brazil
5
Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas 96010-610, Brazil
6
Department of Biotechnology, Federal University of Pelotas, Pelotas 96010-610, Brazil
*
Author to whom correspondence should be addressed.
Nanomaterials 2022, 12(7), 1073; https://doi.org/10.3390/nano12071073
Submission received: 19 February 2022 / Revised: 11 March 2022 / Accepted: 16 March 2022 / Published: 25 March 2022
(This article belongs to the Special Issue Nanodispersions Based on Biocompatibility)
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Abstract

Curcumin (CUR) and quercetin (QU) are potential compounds for treatment of brain diseases such as neurodegenerative diseases (ND) because of their anti-inflammatory and antioxidant properties. However, low water solubility and poor bioavailability hinder their clinical use. In this context, nanotechnology arises as a strategy to overcome biopharmaceutical issues. In this work, we develop, characterize, compare, and optimize three different omega-3 (ω-3) fatty acids nanoemulsions (NEs) loaded with CUR and QU (negative, cationic, gelling) prepared by two different methods for administration by intranasal route (IN). The results showed that formulations prepared with the two proposed methods exhibited good stability and were able to incorporate a similar amount of CUR and QU. On the other side, differences in size, zeta potential, in vitro release kinetics, and permeation/retention test were observed. Considering the two preparation methods tested, high-pressure homogenization (HPH) shows advantages, and the CQ NE- obtained demonstrated potential for sustained release. Toxicity studies demonstrated that the formulations were not toxic for Caenorhabditis elegans. The developed ω-3 fatty acid NEs have shown a range of interesting properties for the treatment of brain diseases, since they have the potential to increase the nose-to-brain permeation of CUR and QU, enabling enhanced treatments efficiency.
Keywords: nanoemulsions; curcumin; quercetin; intranasal administration; toxicity nanoemulsions; curcumin; quercetin; intranasal administration; toxicity

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MDPI and ACS Style

Vaz, G.R.; Carrasco, M.C.F.; Batista, M.M.; Barros, P.A.B.; Oliveira, M.d.C.; Muccillo-Baisch, A.L.; Yurgel, V.C.; Buttini, F.; Soares, F.A.A.; Cordeiro, L.M.; et al. Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration. Nanomaterials 2022, 12, 1073. https://doi.org/10.3390/nano12071073

AMA Style

Vaz GR, Carrasco MCF, Batista MM, Barros PAB, Oliveira MdC, Muccillo-Baisch AL, Yurgel VC, Buttini F, Soares FAA, Cordeiro LM, et al. Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration. Nanomaterials. 2022; 12(7):1073. https://doi.org/10.3390/nano12071073

Chicago/Turabian Style

Vaz, Gustavo Richter, Mariana Corrêa Falkembach Carrasco, Matheus Monteiro Batista, Paula Alice Bezerra Barros, Meliza da Conceição Oliveira, Ana Luiza Muccillo-Baisch, Virginia Campello Yurgel, Francesca Buttini, Félix Alexandre Antunes Soares, Larissa Marafiga Cordeiro, and et al. 2022. "Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration" Nanomaterials 12, no. 7: 1073. https://doi.org/10.3390/nano12071073

APA Style

Vaz, G. R., Carrasco, M. C. F., Batista, M. M., Barros, P. A. B., Oliveira, M. d. C., Muccillo-Baisch, A. L., Yurgel, V. C., Buttini, F., Soares, F. A. A., Cordeiro, L. M., Fachel, F., Teixeira, H. F., Bidone, J., de Oliveira, P. D., Sonvico, F., & Dora, C. L. (2022). Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration. Nanomaterials, 12(7), 1073. https://doi.org/10.3390/nano12071073

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