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Nanomaterials
Volume 11
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10.3390/nano11030617
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Article

Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering

by
Ji-Bong Choi
1,†,
Yu-Kyoung Kim
1,†,
Seon-Mi Byeon
2,
Jung-Eun Park
1,
Tae-Sung Bae
1,
Yong-Seok Jang
1,* and
Min-Ho Lee
1,*
1
Department of Dental Biomaterials, Institute of Biodegradable Materials, School of Dentistry, Jeonbuk National University, Jeonju-si 54896, Jeollabuk-do, Korea
2
Dental Clinic of Ebarun, Suncheon-si 57999, Jeollanam-do, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to the paper.
Nanomaterials 2021, 11(3), 617; https://doi.org/10.3390/nano11030617
Submission received: 21 January 2021 / Revised: 4 February 2021 / Accepted: 15 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Novel Nano-Engineered Biomaterials for Bone Tissue Engineering)
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Abstract

In the field of bone tissue, maintaining adequate mechanical strength and tissue volume is an important part. Recently, biphasic calcium phosphate (BCP) was fabricated to solve the shortcomings of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP), and it is widely studied in the field of bone-tissue engineering. In this study, a composite hydrogel was fabricated by applying BCP to gelatin methacrylate (GelMA). It was tested by using a mechanical tester, to characterize the mechanical properties of the prepared composite hydrogel. The fabricated BCP was analyzed through FTIR and XRD. As a result, a different characteristic pattern from hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) was observed, and it was confirmed that it was successfully bound to the hydrogel. Then, the proliferation and differentiation of preosteoblasts were checked to evaluate cell viability. The analysis results showed high cell viability and relatively high bone differentiation ability in the composite hydrogel to which BCP was applied. These features have been shown to be beneficial for bone regeneration by maintaining the volume and shape of the hydrogel. In addition, hydrogels can be advantageous for clinical use, as they can shape the structure of the material for custom applications.
Keywords: hydrogel; tissue engineering; biphasic calcium phosphate nanoparticle (BCP-NP); biocompatibility; biodegradable; gelatin methacryloyl (GelMA); visible light hydrogel; tissue engineering; biphasic calcium phosphate nanoparticle (BCP-NP); biocompatibility; biodegradable; gelatin methacryloyl (GelMA); visible light

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MDPI and ACS Style

Choi, J.-B.; Kim, Y.-K.; Byeon, S.-M.; Park, J.-E.; Bae, T.-S.; Jang, Y.-S.; Lee, M.-H. Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering. Nanomaterials 2021, 11, 617. https://doi.org/10.3390/nano11030617

AMA Style

Choi J-B, Kim Y-K, Byeon S-M, Park J-E, Bae T-S, Jang Y-S, Lee M-H. Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering. Nanomaterials. 2021; 11(3):617. https://doi.org/10.3390/nano11030617

Chicago/Turabian Style

Choi, Ji-Bong, Yu-Kyoung Kim, Seon-Mi Byeon, Jung-Eun Park, Tae-Sung Bae, Yong-Seok Jang, and Min-Ho Lee. 2021. "Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering" Nanomaterials 11, no. 3: 617. https://doi.org/10.3390/nano11030617

APA Style

Choi, J.-B., Kim, Y.-K., Byeon, S.-M., Park, J.-E., Bae, T.-S., Jang, Y.-S., & Lee, M.-H. (2021). Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering. Nanomaterials, 11(3), 617. https://doi.org/10.3390/nano11030617

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