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Aloe Vera-Mediated Te Nanostructures: Highly Potent Antibacterial Agents and Moderated Anticancer Effects

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA
Nanomedicine Science and Technology Center, Northeastern University, Boston, MA 02115, USA
Stanford Cardiovascular Institute, Stanford, CA 94305, USA
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Instituto de Micro y Nanotecnología, IMN-CNM, CSIC (CEI UAM+CSIC), Isaac Newton 8, 28760 Tres Cantos, Spain
Materials Science Factory, Instituto de Ciencia de Materiales de Madrid, ICMM-CSIC, Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain
Department of Physics and Astronomy, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, AR 72204, USA
School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501, Monterrey, NL 64849, Mexico
Carl Zeiss SMT, Inc., PCS Integration Center, Peabody, MA 01960, USA
Authors to whom correspondence should be addressed.
Academic Editor:   Constantine D. Stalikas
Nanomaterials 2021, 11(2), 514;
Received: 17 December 2020 / Revised: 1 February 2021 / Accepted: 9 February 2021 / Published: 18 February 2021
Cancer and antimicrobial resistance to antibiotics are two of the most worrying healthcare concerns that humanity is facing nowadays. Some of the most promising solutions for these healthcare problems may come from nanomedicine. While the traditional synthesis of nanomaterials is often accompanied by drawbacks such as high cost or the production of toxic by-products, green nanotechnology has been presented as a suitable solution to overcome such challenges. In this work, an approach for the synthesis of tellurium (Te) nanostructures in aqueous media has been developed using aloe vera (AV) extracts as a unique reducing and capping agent. Te-based nanoparticles (AV-TeNPs), with sizes between 20 and 60 nm, were characterized in terms of physicochemical properties and tested for potential biomedical applications. A significant decay in bacterial growth after 24 h was achieved for both Methicillin-resistant Staphylococcus aureus and multidrug-resistant Escherichia coli at a relative low concentration of 5 µg/mL, while there was no cytotoxicity towards human dermal fibroblasts after 3 days of treatment. AV-TeNPs also showed anticancer properties up to 72 h within a range of concentrations between 5 and 100 µg/mL. Consequently, here, we present a novel and green approach to produce Te-based nanostructures with potential biomedical applications, especially for antibacterial and anticancer applications. View Full-Text
Keywords: nanoparticles; aloe vera; tellurium; biomedical; antibacterial; anticancer nanoparticles; aloe vera; tellurium; biomedical; antibacterial; anticancer
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MDPI and ACS Style

Medina-Cruz, D.; Vernet-Crua, A.; Mostafavi, E.; González, M.U.; Martínez, L.; III, A.-A.D.J.; Kusper, M.; Sotelo, E.; Gao, M.; Geoffrion, L.D.; Shah, V.; Guisbiers, G.; Cholula-Díaz, J.L.; Guillermier, C.; Khanom, F.; Huttel, Y.; García-Martín, J.M.; Webster, T.J. Aloe Vera-Mediated Te Nanostructures: Highly Potent Antibacterial Agents and Moderated Anticancer Effects. Nanomaterials 2021, 11, 514.

AMA Style

Medina-Cruz D, Vernet-Crua A, Mostafavi E, González MU, Martínez L, III A-ADJ, Kusper M, Sotelo E, Gao M, Geoffrion LD, Shah V, Guisbiers G, Cholula-Díaz JL, Guillermier C, Khanom F, Huttel Y, García-Martín JM, Webster TJ. Aloe Vera-Mediated Te Nanostructures: Highly Potent Antibacterial Agents and Moderated Anticancer Effects. Nanomaterials. 2021; 11(2):514.

Chicago/Turabian Style

Medina-Cruz, David, Ada Vernet-Crua, Ebrahim Mostafavi, María U. González, Lidia Martínez, A-Andrew D.J. III, Matthew Kusper, Eduardo Sotelo, Ming Gao, Luke D. Geoffrion, Veer Shah, Grégory Guisbiers, Jorge L. Cholula-Díaz, Christelle Guillermier, Fouzia Khanom, Yves Huttel, José M. García-Martín, and Thomas J. Webster. 2021. "Aloe Vera-Mediated Te Nanostructures: Highly Potent Antibacterial Agents and Moderated Anticancer Effects" Nanomaterials 11, no. 2: 514.

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