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Article

Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study

1
Faculty of Dentistry, Colegio Máximo de Cartuja s/n, University of Granada, 18071 Granada, Spain
2
Analytic Chemistry Department, Faculty of Sciences, Campus Fuentenueva s/n, University of Granada, 18071 Granada, Spain
3
NanoMyP, Spin-Off Company, Edificio BIC-Granada, Av. Innovación s/n, Armilla, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: May Lei Mei
Nanomaterials 2021, 11(11), 3150; https://doi.org/10.3390/nano11113150
Received: 22 October 2021 / Revised: 10 November 2021 / Accepted: 16 November 2021 / Published: 22 November 2021
(This article belongs to the Special Issue Nanomaterials in Dentistry)
Tubule occlusion and remineralization are considered the two main goals of dentin hypersensitivity treatment. The objective is to assess the ability of dentifrices containing zinc-doped polymeric nanoparticles (NPs) to enduringly occlude the dentinal tubules, reinforcing dentin’s mechanical properties. Fifteen dentin surfaces were acid-treated for dentinal tubule exposure and brushed with (1) distilled water, or with experimental pastes containing (2) 1% of zinc-doped NPs, (3) 5% of zinc-doped NPs, (4) 10% of zinc-doped NPs or (5) Sensodyne®. Topographical and nanomechanical analyses were performed on treated dentin surfaces and after a citric acid challenge. ANOVA and Student–Newman–Keuls tests were used (p < 0.05). The main results indicate that all pastes produced tubule occlusion (100%) and reinforced mechanical properties of intertubular dentin (complex modulus was above 75 GPa). After the citric acid challenge, only those pastes containing zinc-doped NPs were able to maintain tubular occlusion, as specimens treated with Sensodyne® have around 30% of tubules opened. Mechanical properties were maintained for dentin treated with Zn-doped NPs, but in the case of specimens treated with Sensodyne®, complex modulus values were reduced below 50 GPa. It may be concluded that zinc-doped NPs at the lowest tested concentration produced acid-resistant tubular occlusion and increased the mechanical properties of dentin. View Full-Text
Keywords: nanoparticles; zinc; dentin hypersensitivity; dentinal tubules; dentifrice nanoparticles; zinc; dentin hypersensitivity; dentinal tubules; dentifrice
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MDPI and ACS Style

Toledano-Osorio, M.; Osorio, R.; Osorio, E.; Medina-Castillo, A.L.; Toledano, M. Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study. Nanomaterials 2021, 11, 3150. https://doi.org/10.3390/nano11113150

AMA Style

Toledano-Osorio M, Osorio R, Osorio E, Medina-Castillo AL, Toledano M. Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study. Nanomaterials. 2021; 11(11):3150. https://doi.org/10.3390/nano11113150

Chicago/Turabian Style

Toledano-Osorio, Manuel, Raquel Osorio, Estrella Osorio, Antonio L. Medina-Castillo, and Manuel Toledano. 2021. "Novel Pastes Containing Polymeric Nanoparticles for Dentin Hypersensitivity Treatment: An In Vitro Study" Nanomaterials 11, no. 11: 3150. https://doi.org/10.3390/nano11113150

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