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Nanomaterials
Volume 11
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10.3390/nano11010149
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Article

Magnetic Hyperthermia on γ-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection

by
Marie-Charlotte Horny
1,2,3,
Jean Gamby
2,*,
Vincent Dupuis
1 and
Jean-Michel Siaugue
1,*
1
Physico-chimie des Électrolytes et Nanosystèmes Interfaciaux, PHENIX, Sorbonne Université, CNRS, F-75005 Paris, France
2
Centre de Nanosciences et de Nanotechnologies, Université Paris-Saclay, CNRS, 91120 Palaiseau, France
3
Laboratoire Interfaces et Systèmes Electrochimiques, LISE, Sorbonne Université, CNRS, F-75005 Paris, France
*
Authors to whom correspondence should be addressed.
Nanomaterials 2021, 11(1), 149; https://doi.org/10.3390/nano11010149
Submission received: 18 December 2020 / Revised: 30 December 2020 / Accepted: 5 January 2021 / Published: 9 January 2021
(This article belongs to the Special Issue Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications)
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Abstract

Magnetic hyperthermia on core-shell nanoparticles bears promising achievements, especially in biomedical applications. Here, thanks to magnetic hyperthermia, γ-Fe2O3 cores are able to release a DNA target mimicking the liver specific oncotarget miRNA-122. Our silica coated magnetic nanoparticles not only allow the grafting at their surface of a significant number of oligonucleotides but are also shown to be as efficient, by local heating, as 95 °C global heating when submitted to an alternative magnetic field, while keeping the solution at 28 °C, crucial for biological media and energy efficiency. Moreover, a slight modification of the silica coating process revealed an increased heating power, well adapted for the release of small oligonucleotides such as microRNA.
Keywords: nucleic acids; magnetic hyperthermia; core-shell nanoparticles; early diagnosis nucleic acids; magnetic hyperthermia; core-shell nanoparticles; early diagnosis

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MDPI and ACS Style

Horny, M.-C.; Gamby, J.; Dupuis, V.; Siaugue, J.-M. Magnetic Hyperthermia on γ-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection. Nanomaterials 2021, 11, 149. https://doi.org/10.3390/nano11010149

AMA Style

Horny M-C, Gamby J, Dupuis V, Siaugue J-M. Magnetic Hyperthermia on γ-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection. Nanomaterials. 2021; 11(1):149. https://doi.org/10.3390/nano11010149

Chicago/Turabian Style

Horny, Marie-Charlotte, Jean Gamby, Vincent Dupuis, and Jean-Michel Siaugue. 2021. "Magnetic Hyperthermia on γ-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection" Nanomaterials 11, no. 1: 149. https://doi.org/10.3390/nano11010149

APA Style

Horny, M.-C., Gamby, J., Dupuis, V., & Siaugue, J.-M. (2021). Magnetic Hyperthermia on γ-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection. Nanomaterials, 11(1), 149. https://doi.org/10.3390/nano11010149

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