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Open AccessArticle

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells

1
Nanomedicine and Molecular Imaging Group, Trinity Translational Medicine Institute, Dublin 8, Ireland
2
Laboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin 8, Ireland
3
Advanced Materials and Bioengineering Research (AMBER) centre, CRANN institute, Trinity College Dublin, Dublin 2, Ireland
4
Department of Histology, Cytology and Embryology, First Moscow State Sechenov Medical University, Moscow 119992, Russia
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(3), 593; https://doi.org/10.3390/nano10030593
Received: 6 February 2020 / Revised: 13 March 2020 / Accepted: 22 March 2020 / Published: 24 March 2020
(This article belongs to the Special Issue Biomedical Applications of Nanotechnology)
Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials in various solid malignancies and subsequently achieved clinical approval to treat glioblastoma and prostate cancer in 2011 and 2018, respectively. However, despite recent clinical advances, many questions remain with regard to the underlying mechanisms involved in this therapy. One such query is whether intracellular or extracellular nanoparticles are necessary for treatment efficacy. Herein, we compare the effects of intracellular and extracellular magnetic hyperthermia in BxPC-3 cells to determine the differences in efficacy between both. Extracellular magnetic hyperthermia at temperatures between 40–42.5 °C could induce significant levels of necrosis in these cells, whereas intracellular magnetic hyperthermia resulted in no change in viability. This led to a discussion on the overall relevance of intracellular nanoparticles to the efficacy of magnetic hyperthermia therapy. View Full-Text
Keywords: magnetic hyperthermia; iron oxide nanoparticles; magnetic nanoparticles; cancer magnetic hyperthermia; iron oxide nanoparticles; magnetic nanoparticles; cancer
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Hannon, G.; Bogdanska, A.; Volkov, Y.; Prina-Mello, A. Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells. Nanomaterials 2020, 10, 593.

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