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Article

Synthesis, Cytotoxicity Assessment and Optical Properties Characterization of Colloidal GdPO4:Mn2+, Eu3+ for High Sensitivity Luminescent Nanothermometers Operating in the Physiological Temperature Range

1
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wroclaw, Poland
2
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, ul. C.K. Norwida 31, 50-366 Wrocław, Poland
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(3), 421; https://doi.org/10.3390/nano10030421
Received: 4 February 2020 / Revised: 19 February 2020 / Accepted: 25 February 2020 / Published: 28 February 2020
(This article belongs to the Special Issue Luminescent Rare-Earth-Based Nanomaterials)
Herein, a novel synthesis method of colloidal GdPO4:Mn2+,Eu3+ nanoparticles for luminescent nanothermometry is proposed. XRD, TEM, DLS, and zeta potential measurements confirmed the crystallographic purity and reproducible morphology of the obtained nanoparticles. The spectroscopic properties of GdPO4:Mn2+,Eu3+ with different amounts of Mn2+ and Eu3+ were analyzed in a physiological temperature range. It was found that GdPO4:1%Eu3+,10%Mn2+ nanoparticles revealed extraordinary performance for noncontact temperature sensing with relative sensitivity SR = 8.88%/°C at 32 °C. Furthermore, the biocompatibility and safety of GdPO4:15%Mn2+,1%Eu3+ was confirmed by cytotoxicity studies. These results indicated that colloidal GdPO4 doped with Mn2+ and Eu3+ is a very promising candidate as a luminescent nanothermometer for in vitro applications. View Full-Text
Keywords: nanoparticles; synthesis; luminescent nanothermometers; transition metals; cytotoxicity; optical properties nanoparticles; synthesis; luminescent nanothermometers; transition metals; cytotoxicity; optical properties
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MDPI and ACS Style

Maciejewska, K.; Poźniak, B.; Tikhomirov, M.; Kobylińska, A.; Marciniak, Ł. Synthesis, Cytotoxicity Assessment and Optical Properties Characterization of Colloidal GdPO4:Mn2+, Eu3+ for High Sensitivity Luminescent Nanothermometers Operating in the Physiological Temperature Range. Nanomaterials 2020, 10, 421. https://doi.org/10.3390/nano10030421

AMA Style

Maciejewska K, Poźniak B, Tikhomirov M, Kobylińska A, Marciniak Ł. Synthesis, Cytotoxicity Assessment and Optical Properties Characterization of Colloidal GdPO4:Mn2+, Eu3+ for High Sensitivity Luminescent Nanothermometers Operating in the Physiological Temperature Range. Nanomaterials. 2020; 10(3):421. https://doi.org/10.3390/nano10030421

Chicago/Turabian Style

Maciejewska, Kamila, Blazej Poźniak, Marta Tikhomirov, Adrianna Kobylińska, and Łukasz Marciniak. 2020. "Synthesis, Cytotoxicity Assessment and Optical Properties Characterization of Colloidal GdPO4:Mn2+, Eu3+ for High Sensitivity Luminescent Nanothermometers Operating in the Physiological Temperature Range" Nanomaterials 10, no. 3: 421. https://doi.org/10.3390/nano10030421

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