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Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics

1
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2 str., 50-422 Wroclaw, Poland
2
Department of Chemistry, University of Wroclaw, F. Joliot-Curie 14 str., 50-383 Wroclaw, Poland
3
Centre for Advanced Materials and Smart Structures, Polish Academy of Sciences, Okolna 2 str., 50-950 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(2), 331; https://doi.org/10.3390/nano10020331
Received: 23 January 2020 / Revised: 6 February 2020 / Accepted: 11 February 2020 / Published: 15 February 2020
This work was aimed to obtain and characterize the well-defined biocomposites based on β-tricalcium diphosphate(V) (β-TCP) co-doped with Ce3+ and Pr3+ ions modified by poly(l-lactide) (PLLA) with precise tailored chain length and different phosphate to polymer ratio. The composites as well as β-tricalcium diphosphate(V) were spectroscopically characterized using emission spectroscopy and luminescence kinetics. Morphological and structural properties were studied using X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The self-assembled poly(l-lactide) in a shape of rose flower has been successfully polymerized on the surface of the β-tricalcium diphosphate(V) nanocrystals. The studied materials were evaluated in vitro including cytotoxicity (MTT assay) and hemolysis tests. The obtained results suggested that the studied materials may find potential application in tissue engineering. View Full-Text
Keywords: β-tricalcium diphosphate(V); Ce3+ and Pr3+ ions co-doping; poly(l-lactide); theranostics β-tricalcium diphosphate(V); Ce3+ and Pr3+ ions co-doping; poly(l-lactide); theranostics
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MDPI and ACS Style

Zienkiewicz, J.A.; Strzep, A.; Jedrzkiewicz, D.; Nowak, N.; Rewak-Soroczynska, J.; Watras, A.; Ejfler, J.; Wiglusz, R.J. Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics. Nanomaterials 2020, 10, 331.

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